Technology Process of 1-[(3-chloro-2-methylphenyl)methyl]-6-(4-morpholinyl)-4-(4H-1,2,4-triazol-3-yl)-2-(trifluoromethyl)-1H-benzimidazole
There total 11 articles about 1-[(3-chloro-2-methylphenyl)methyl]-6-(4-morpholinyl)-4-(4H-1,2,4-triazol-3-yl)-2-(trifluoromethyl)-1H-benzimidazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrazine hydrate; acetic acid;
at 100 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: potassium tert-butylate; N-methoxylamine hydrochloride / copper diacetate / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere
1.2: pH 1
2.1: triethylamine; HATU / tetrahydrofuran / 3 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C
4.1: hydrogen / palladium on activated charcoal / methanol / 3 h / 20 °C / 3040.2 Torr / autoclave
5.1: 8 h / Reflux
6.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
6.2: 3 h / 80 °C
7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 70 °C
7.2: pH 4
8.1: oxalyl dichloride / dichloromethane / 0.17 h / 20 °C
9.1: ammonia / tetrahydrofuran / 0.25 h / 20 °C
10.1: 2 h / 105 °C
11.1: hydrazine hydrate; acetic acid / 1.5 h / 100 °C
With
oxalyl dichloride; potassium tert-butylate; ammonia; water; hydrogen; N-methoxylamine hydrochloride; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; HATU; sodium hydroxide;
palladium on activated charcoal; copper diacetate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: triethylamine; HATU / tetrahydrofuran / 3 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C
3.1: hydrogen / palladium on activated charcoal / methanol / 3 h / 20 °C / 3040.2 Torr / autoclave
4.1: 8 h / Reflux
5.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
5.2: 3 h / 80 °C
6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 70 °C
6.2: pH 4
7.1: oxalyl dichloride / dichloromethane / 0.17 h / 20 °C
8.1: ammonia / tetrahydrofuran / 0.25 h / 20 °C
9.1: 2 h / 105 °C
10.1: hydrazine hydrate; acetic acid / 1.5 h / 100 °C
With
oxalyl dichloride; ammonia; water; hydrogen; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; HATU; sodium hydroxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
