4,4-diphenylbutyraldehyde

Base Information

• Chemical Name: 4,4-diphenylbutyraldehyde
• CAS No.: 38151-56-3
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.302
• Mol file: 38151-56-3.mol

Synonyms:4,4-diphenylbutyraldehyde

Chemical Property of 4,4-diphenylbutyraldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-diphenylbutyraldehyde

There total 11 articles about 4,4-diphenylbutyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,3-diphenylpropionitrile (22156-48-5) → 4,4-diphenylbutyraldehyde (38151-56-3)

Guidance literature:

3,3-diphenylpropionitrile; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 3h;

With water; In dichloromethane;

DOI:10.1002/anie.201609110

Reference yield: 22.0%

1,1-diphenyl-4-bromobutane (36265-55-1) → 4,4-diphenylbutyraldehyde (38151-56-3) + 4,4-diphenyl-1-butanol (56740-71-7)

Guidance literature:

With sodium hydrogencarbonate; sodium iodide; In dimethyl sulfoxide; at 110 ℃; for 2h;

DOI:10.1021/jm00112a032

Reference yield:

4,4-diphenyl-3-butenyl bromide (6078-95-1) → 4,4-diphenylbutyraldehyde (38151-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / ethanol

2: 60 percent / sodium iodide, sodium hydrogen carbonate / dimethylsulfoxide / 2 h / 110 °C

With hydrogen; sodium hydrogencarbonate; sodium iodide; palladium on activated charcoal; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00112a032

upstream raw materials:

4,4-diphenylbutanoic acid

4,4-diphenyl-1-butanol

1,1-diphenyl-4-bromobutane

4,4-diphenyl-3-butenyl bromide

Downstream raw materials:

4,5-bis(chloromethyl)-2-(3,3-diphenylpropyl)-[1,3]dioxolane

4⁽⁵⁾-(2,2-Diphenylethyl)imidazole

Refernces

• 1、 -. "Method of preparing optically active homo-beta-amino acids". . . Retrieved 2008/06/13.
• 2、 Cordi,Snyers,Giraud-Mangin,Van der Maesen,Van Hoeck,Beuze,Ellens,Napora,Gillet,Gorissen,Calderon,Remacle,Janssens de Varebeke,Van Dorsser,Roba. "Synthesis and structure-activity of 4(5)-(2,2-diphenylethyl)imidazoles as new α2-adrenoreceptor antagonists". . p. 557 - 568. Retrieved 2007/10/02.