(S,S)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)pyrrolidine-2-carboxylic acid benzyl ester

Base Information

Chemical Name:(S,S)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:1312547-74-2
Molecular Formula:C₂₅H₃₀N₂O₅
Molecular Weight:438.524
Hs Code.:

Synonyms:(S,S)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Property of (S,S)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of (S,S)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)pyrrolidine-2-carboxylic acid benzyl ester

There total 2 articles about (S,S)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 41324-66-7
H-Pro-OBzl

: 1312547-74-2
(S,S)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.049

Reference yield:

: 1312547-74-2
(S,S)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1312547-74-2
(S,S)-1-(2-tert-butoxycarbonylamino-2-phenylacetyl)pyrrolidine-2-carboxylic acid benzyl ester

: C₃₅H₄₂N₄O₅

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

3: palladium on carbon; hydrogen / methanol

4: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

With 4-methyl-morpholine; palladium on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.049