4-{[tert-butoxycarbonyl-(2-ethoxycarbonyl-ethyl)-amino]-methyl}-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-{[tert-butoxycarbonyl-(2-ethoxycarbonyl-ethyl)-amino]-methyl}-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester
• CAS No.: 913368-48-6
• Molecular Formula: C₂₉H₃₃Cl₂N₃O₆
• Molecular Weight: 590.504

Synonyms:4-{[tert-butoxycarbonyl-(2-ethoxycarbonyl-ethyl)-amino]-methyl}-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property of 4-{[tert-butoxycarbonyl-(2-ethoxycarbonyl-ethyl)-amino]-methyl}-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

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Technology Process of 4-{[tert-butoxycarbonyl-(2-ethoxycarbonyl-ethyl)-amino]-methyl}-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

There total 1 articles about 4-{[tert-butoxycarbonyl-(2-ethoxycarbonyl-ethyl)-amino]-methyl}-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-4-[(2-ethoxycarbonyl-ethylamino)-methyl]-1H-pyrazole-3-carboxylic acid ethyl ester (913368-47-5) + di-tert-butyl dicarbonate (24424-99-5) → 4-{[tert-butoxycarbonyl-(2-ethoxycarbonyl-ethyl)-amino]-methyl}-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (913368-48-6)

Guidance literature:

With dmap; In dichloromethane; for 6h; Heating / reflux;

Reference yield: 43.0%

4-{[tert-butoxycarbonyl-(2-ethoxycarbonyl-ethyl)-amino]-methyl}-1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (913368-48-6) → 2-(2-chloro-phenyl)-3-(4-chloro-phenyl)-8-oxo-2,6,7,8-tetrahydro-4H-1,2,5-triaza-azulene-5,7-dicarboxylic acid 5-tert-butyl ester 7-ethyl ester (913368-49-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 17h;

upstream raw materials:

1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-4-[(2-ethoxycarbonyl-ethylamino)-methyl]-1H-pyrazole-3-carboxylic acid ethyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

2-(2-chloro-phenyl)-3-(4-chloro-phenyl)-8-oxo-2,6,7,8-tetrahydro-4H-1,2,5-triaza-azulene-5,7-dicarboxylic acid 5-tert-butyl ester 7-ethyl ester

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