(5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane

Base Information

Chemical Name:(5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane
CAS No.:1448328-51-5
Molecular Formula:C₂₆H₄₆O₄Si₂
Molecular Weight:478.82
Hs Code.:

Synonyms:(5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane

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Chemical Property of (5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane

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Technology Process of (5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane

There total 2 articles about (5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₂O₄

: 1448328-51-5
(5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / methanol / 8 h

2: 1H-imidazole / N,N-dimethyl-formamide / 12 h

With 1H-imidazole; hydrogenchloride; water; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201208919

Reference yield:

: 149859-05-2
1-[2',2'-dimethyl-(4'R)-1',3'-dioxolan-4'-yl]-(1S)-3-butyn-1-ol

: 1448328-51-5
(5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 16.5 h / 0 - 60 °C

2.1: hydrogenchloride; water / methanol / 8 h

3.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h

With 1H-imidazole; hydrogenchloride; water; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/anie.201208919

Reference yield: 54.0%

: 1448328-51-5
(5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane

: 203913-56-8
(E)-8-(benzyloxy)oct-4-enal

: 1448328-52-6
(2R,3S,7S,E)-14-(benzyloxy)-1,2-bis((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)tetradec-10-en-5-yn-7-ol

Guidance literature:: (5R)-5-((S)-1-((4-methoxybenzyl)oxy)but-3-yn-1-yl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane; With (-)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine; In toluene; at 20 ℃; for 1.5h; Inert atmosphere;

(E)-8-(benzyloxy)oct-4-enal; In toluene; at 20 ℃; for 21h; stereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201208919