(+)-(4S,5R)-1,5-dimethyl-4-phenyl-3-(3,4-dimethoxyphenylacetyl)-2-imidazolidinone

Base Information

Chemical Name:(+)-(4S,5R)-1,5-dimethyl-4-phenyl-3-(3,4-dimethoxyphenylacetyl)-2-imidazolidinone
CAS No.:225089-82-7
Molecular Formula:C₂₁H₂₄N₂O₄
Molecular Weight:368.433
Hs Code.:

Synonyms:(+)-(4S,5R)-1,5-dimethyl-4-phenyl-3-(3,4-dimethoxyphenylacetyl)-2-imidazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(4S,5R)-1,5-dimethyl-4-phenyl-3-(3,4-dimethoxyphenylacetyl)-2-imidazolidinone

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Technology Process of (+)-(4S,5R)-1,5-dimethyl-4-phenyl-3-(3,4-dimethoxyphenylacetyl)-2-imidazolidinone

There total 2 articles about (+)-(4S,5R)-1,5-dimethyl-4-phenyl-3-(3,4-dimethoxyphenylacetyl)-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 169125-10-4
(4S,5R)-1,5-dimethyl-4-phenyl-3-trimethylsilyl-2-imidazolidinone

: 225089-82-7
(+)-(4S,5R)-1,5-dimethyl-4-phenyl-3-(3,4-dimethoxyphenylacetyl)-2-imidazolidinone

Guidance literature:: With tetrabutyl ammonium fluoride; In acetonitrile; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(98)01147-8

Reference yield:

: 112791-04-5
(4R,5S)-3,4-dimethyl-5-phenyl-imidazolidin-2-one

: 225089-82-7
(+)-(4S,5R)-1,5-dimethyl-4-phenyl-3-(3,4-dimethoxyphenylacetyl)-2-imidazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) BuLi, Ph₃CH / 1) THF, 0 deg C, 2) THF, -78 deg C to room temperature

2: 70 percent / TBAF / acetonitrile / 24 h / Ambient temperature

With n-butyllithium; triphenylmethane; tetrabutyl ammonium fluoride; In acetonitrile;
DOI:10.1016/S0040-4020(98)01147-8

Reference yield:

: 225089-82-7
(+)-(4S,5R)-1,5-dimethyl-4-phenyl-3-(3,4-dimethoxyphenylacetyl)-2-imidazolidinone

: (S)-3',4'-dimethoxyisoflavan

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithium isopropylcyclohexylamide / 1) THF, -78 deg C to -50 deg C, 2) THF, DCM, -40 deg C, 2 h

2: 86 percent / LiBH₄ / diethyl ether; tetrahydrofuran / 18 h / Ambient temperature

3: 3M HCl / methanol / 1 h / Heating

4: 85 percent / Ph₃P, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature

With hydrogenchloride; lithium borohydride; lithium cyclohexylisopropylamide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/S0040-4020(98)01147-8