4-(3-formylphenyl)-3-hydroxy-2(1H)-pyridone

Base Information

Chemical Name:4-(3-formylphenyl)-3-hydroxy-2(1H)-pyridone
CAS No.:1298062-79-9
Molecular Formula:C₁₂H₉NO₃
Molecular Weight:215.208
Hs Code.:

Synonyms:4-(3-formylphenyl)-3-hydroxy-2(1H)-pyridone

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Chemical Property of 4-(3-formylphenyl)-3-hydroxy-2(1H)-pyridone

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Technology Process of 4-(3-formylphenyl)-3-hydroxy-2(1H)-pyridone

There total 2 articles about 4-(3-formylphenyl)-3-hydroxy-2(1H)-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1298062-78-8
2-benzyloxy-4-(3-formylphenyl)-3-methoxymethoxypyridine

: 1298062-79-9
4-(3-formylphenyl)-3-hydroxy-2(1H)-pyridone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ja200580x

Reference yield:

: 2-benzyloxy-3-(methoxymethoxy)pyridine

: 1298062-79-9
4-(3-formylphenyl)-3-hydroxy-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran; hexane / 0.83 h / -80 °C

1.2: -80 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 24 h / Reflux; Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene; 2.1: Suzuki coupling;
DOI:10.1021/ja200580x

Reference yield:

: 52462-29-0
[ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂

: 1298062-79-9
4-(3-formylphenyl)-3-hydroxy-2(1H)-pyridone

: [((p-cymene)Ru(O2C5H2N(C6H4CHO)))3]

Guidance literature:: With Cs₂CO₃; In methanol; dichloromethane; ruthenium compd. and 2-pyridone deriv. in the presence of Cs2CO3 in CH2Cl2/methanol at room temp.;
DOI:10.1021/ja200580x