Acetamide, N-((2,5-dimethoxyphenyl)methyl)-2-(fluoro-18F)-N-(2-phenoxyphenyl)-

Base Information

Chemical Name:Acetamide, N-((2,5-dimethoxyphenyl)methyl)-2-(fluoro-18F)-N-(2-phenoxyphenyl)-
CAS No.:1003581-94-9
Molecular Formula:C₂₃H₂₂FNO₄
Molecular Weight:394.432
Hs Code.:
UNII:41TIZ5663Z
ChEMBL ID:CHEMBL480193
Wikidata:Q27258462

Synonyms:(18F)N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline;18F-PBR06;N-fluoroacetyl-2MeOBzPhOA;N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline

Suppliers and Price of Acetamide, N-((2,5-dimethoxyphenyl)methyl)-2-(fluoro-18F)-N-(2-phenoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Acetamide, N-((2,5-dimethoxyphenyl)methyl)-2-(fluoro-18F)-N-(2-phenoxyphenyl)-

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:394.155821
Heavy Atom Count:29
Complexity:499

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)OC)CN(C2=CC=CC=C2OC3=CC=CC=C3)C(=O)CF
Isomeric SMILES:COC1=CC(=C(C=C1)OC)CN(C2=CC=CC=C2OC3=CC=CC=C3)C(=O)C[18F]
Recent ClinicalTrials:Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement Disorders

Technology Process of Acetamide, N-((2,5-dimethoxyphenyl)methyl)-2-(fluoro-18F)-N-(2-phenoxyphenyl)-

There total 6 articles about Acetamide, N-((2,5-dimethoxyphenyl)methyl)-2-(fluoro-18F)-N-(2-phenoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1104493-09-5
2-bromo-N-(2,5-dimethoxybenzyl)-N-(2-phenoxyphenyl)acetamide

: 1003581-94-9
[¹⁸F]N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline

Guidance literature:: With 18-crown-6 ether; potassium hydrogencarbonate; [18F]fluoride ion, cyclotron produced, NCA; In water; acetonitrile; at 110 ℃; for 0.166667h; Inert atmosphere; sealed vial;
DOI:10.1021/jm8011855

Reference yield:

: 1334484-14-8
2-((2,5-dimethoxybenzyl)(2-phenoxyphenyl)amino)-2-oxoethyl-4-methylbenzenesulfonate

: 1003581-94-9
[¹⁸F]N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline

Guidance literature:: With [¹⁸F]-hydrofluoric acid; [2.2.2]cryptande; In dimethyl sulfoxide; at 140 ℃; for 0.25h;
DOI:10.1016/j.steroids.2011.06.012

Reference yield:

: C₂₁H₁₉NO₃

: 1003581-94-9
[¹⁸F]N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C

3: [¹⁸F]-hydrofluoric acid; [2.2.2]cryptande / dimethyl sulfoxide / 0.25 h / 140 °C

With [¹⁸F]-hydrofluoric acid; sodium tetrahydroborate; triethylamine; [2.2.2]cryptande; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.steroids.2011.06.012