benzyl (6R,8S,11S,14S)-14-[4-(benzyloxy)benzyl]-11-[(4,4'-bis(benzyloxy)-3'-{2-{ [(benzyloxy) carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)methyl]-8-[(tert-butoxycarbonyl)amino]-6-([tert-butyl(dimethyl)silyl]oxy)-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate

Base Information

• Chemical Name: benzyl (6R,8S,11S,14S)-14-[4-(benzyloxy)benzyl]-11-[(4,4'-bis(benzyloxy)-3'-{2-{ [(benzyloxy) carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)methyl]-8-[(tert-butoxycarbonyl)amino]-6-([tert-butyl(dimethyl)silyl]oxy)-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate
• CAS No.: 868073-47-6
• Molecular Formula: C₉₂H₁₀₉N₅O₁₆Si₂
• Molecular Weight: 1597.07

Synonyms:benzyl (6R,8S,11S,14S)-14-[4-(benzyloxy)benzyl]-11-[(4,4'-bis(benzyloxy)-3'-{2-{ [(benzyloxy) carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)methyl]-8-[(tert-butoxycarbonyl)amino]-6-([tert-butyl(dimethyl)silyl]oxy)-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate

Chemical Property of benzyl (6R,8S,11S,14S)-14-[4-(benzyloxy)benzyl]-11-[(4,4'-bis(benzyloxy)-3'-{2-{ [(benzyloxy) carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)methyl]-8-[(tert-butoxycarbonyl)amino]-6-([tert-butyl(dimethyl)silyl]oxy)-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate

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Technology Process of benzyl (6R,8S,11S,14S)-14-[4-(benzyloxy)benzyl]-11-[(4,4'-bis(benzyloxy)-3'-{2-{ [(benzyloxy) carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)methyl]-8-[(tert-butoxycarbonyl)amino]-6-([tert-butyl(dimethyl)silyl]oxy)-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate

There total 1 articles about benzyl (6R,8S,11S,14S)-14-[4-(benzyloxy)benzyl]-11-[(4,4'-bis(benzyloxy)-3'-{2-{ [(benzyloxy) carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)methyl]-8-[(tert-butoxycarbonyl)amino]-6-([tert-butyl(dimethyl)silyl]oxy)-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(2S,4R)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}pentanoic acid (636594-67-7) + 2-(trimethylsilyl)ethyl 3-[3'-[(2S)-2-amino-3-({(1S)-2-(benzyloxy)-1-[4-(benzyloxy)benzyl]-2-oxoethyl} amino)-3-oxopropyl]-4,4'-bis(benzyloxy)biphenyl-3-yl]-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride → benzyl (6R,8S,11S,14S)-14-[4-(benzyloxy)benzyl]-11-[(4,4'-bis(benzyloxy)-3'-{2-{ [(benzyloxy) carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)methyl]-8-[(tert-butoxycarbonyl)amino]-6-([tert-butyl(dimethyl)silyl]oxy)-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate (868073-47-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 96h;

Reference yield:

benzyl (6R,8S,11S,14S)-14-[4-(benzyloxy)benzyl]-11-[(4,4'-bis(benzyloxy)-3'-{2-{ [(benzyloxy) carbonyl]amino}-3-oxo-3-[2-(trimethylsilyl)ethoxy]propyl}biphenyl-3-yl)methyl]-8-[(tert-butoxycarbonyl)amino]-6-([tert-butyl(dimethyl)silyl]oxy)-3,9,12-trioxo-1-phenyl-2-oxa-4,10,13-triazapentadecan-15-oate (868073-47-6) → 2-{[(benzyloxy)carbonyl]amino}-3-{4,4'-bis(benzyloxy)-3'-[(2S)-3-({(1S)-2-(benzyloxy)-1-[4-(benzyloxy)benzyl]-2-oxoethyl}amino)-2-({(2S,4R)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]-4-hydroxypentanoyl}amino)-3-oxopropyl]biphenyl-3-yl}propanoic acid (868073-48-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 5h;

upstream raw materials:

(2S,4R)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}pentanoic acid

Downstream raw materials:

2-{[(benzyloxy)carbonyl]amino}-3-{4,4'-bis(benzyloxy)-3'-[(2S)-3-({(1S)-2-(benzyloxy)-1-[4-(benzyloxy)benzyl]-2-oxoethyl}amino)-2-({(2S,4R)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]-4-hydroxypentanoyl}amino)-3-oxopropyl]biphenyl-3-yl}propanoic acid

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