(S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-fluorophenyl)-5-methyl-2-oxindole

Base Information

Chemical Name:(S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-fluorophenyl)-5-methyl-2-oxindole
CAS No.:1361563-52-1
Molecular Formula:C₂₀H₁₉F₂NO₃
Molecular Weight:359.373
Hs Code.:

Synonyms:(S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-fluorophenyl)-5-methyl-2-oxindole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-fluorophenyl)-5-methyl-2-oxindole

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Technology Process of (S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-fluorophenyl)-5-methyl-2-oxindole

There total 2 articles about (S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-fluorophenyl)-5-methyl-2-oxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 923568-88-1
tert-butyl 3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

: 1361563-52-1
(S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-fluorophenyl)-5-methyl-2-oxindole

Guidance literature:: With (DHQD)₂PHAL; 4-(tert-butyl)-N-((4-(tert-butyl)phenyl)sulfonyl)-N-fluorobenzenesulfonamide; potassium carbonate; In dichloromethane; acetonitrile; at -80 ℃; for 96h; Time; Reagent/catalyst; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2013.04.037

Reference yield:

: 923568-88-1
tert-butyl 3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

: 1361563-52-1
(S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-fluorophenyl)-5-methyl-2-oxindole

: (R)-N-tert-butoxycarbonyl-3-fluoro-3-(4-fluorophenyl)-5-methyl-2-oxindole

Guidance literature:: With (DHQD)₂PHAL; potassium carbonate; N-fluorobis(benzenesulfon)imide; In dichloromethane; acetonitrile; at -80 ℃; for 48h; Time; Reagent/catalyst; Overall yield = 68 %; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2013.04.037