(3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione

Base Information

• Chemical Name: (3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione
• CAS No.: 371252-64-1
• Molecular Formula: C₄₆H₅₆N₂O₆Si₂
• Molecular Weight: 789.131
• Mol file: 371252-64-1.mol

Synonyms:(3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione

Chemical Property of (3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione

There total 3 articles about (3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(3S,3'S)-1,1'-Dibenzyl-3'-[(R)-2-hydroxy-3-(2-trimethylsilanyl-ethoxy)-propyl]-3-[(S)-2-hydroxy-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione (371252-58-3) → (3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione (371252-64-1)

Guidance literature:

With dipyridinium dichromate; In acetonitrile; at 20 ℃;

DOI:10.1021/ja0166141

Reference yield:

2,2'-((3S,3'S)-1,1'-dibenzyl-2,2'-dioxo-[3,3'-biindoline]-3,3'-diyl)diacetaldehyde (371252-55-0) → (3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione (371252-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: MgBr₂*OEt₂ / tetrahydrofuran / -40 - 0 °C

1.3: 42 percent / tetrahydrofuran

2.1: 88 percent / PDC / acetonitrile / 20 °C

With dipyridinium dichromate; n-butyllithium; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ja0166141

Reference yield:

C34H30N2O4 → (3S,3'S)-1,1'-Dibenzyl-3,3'-bis-[2-oxo-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione (371252-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / aq. NaIO₄ / tetrahydrofuran / 20 °C

2.1: n-BuLi / tetrahydrofuran / -78 °C

2.2: MgBr₂*OEt₂ / tetrahydrofuran / -40 - 0 °C

2.3: 42 percent / tetrahydrofuran

3.1: 88 percent / PDC / acetonitrile / 20 °C

With sodium periodate; dipyridinium dichromate; n-butyllithium; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ja0166141

upstream raw materials:

(3S,3'S)-1,1'-Dibenzyl-3'-[(R)-2-hydroxy-3-(2-trimethylsilanyl-ethoxy)-propyl]-3-[(S)-2-hydroxy-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione

2,2'-((3S,3'S)-1,1'-dibenzyl-2,2'-dioxo-[3,3'-biindoline]-3,3'-diyl)diacetaldehyde

Downstream raw materials:

C₈₂H₉₂N₆O₈Si₂

C₇₂H₆₈N₆O₈

(3S,3'S)-3,3'-Bis-[(S)-2-azido-3-(2-trimethylsilanyl-ethoxy)-propyl]-1,1'-dibenzyl-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione

(2S,3aS,8aR,2'S,3'aS,8'aR)-8,8'-Dibenzyl-2,2'-bis-(2-trimethylsilanyl-ethoxymethyl)-2,3,8,8a,2',3',8',8'a-octahydro-1H,1'H-[3a,3'a]bi[pyrrolo[2,3-b]indolyl]