4-Bromo-3-fluoro-2-nitrophenol

Base Information

Chemical Name:4-Bromo-3-fluoro-2-nitrophenol
CAS No.:889939-22-4
Molecular Formula:C₆H₃BrFNO₃
Molecular Weight:235.997
Hs Code.:2904990090
DSSTox Substance ID:DTXSID301305408

Synonyms:4-BROMO-3-FLUORO-2-NITROPHENOL;889939-22-4;4-bromo-2-nitro-fluorphenol;4-bromo-2-nitro-fluorophenol;SCHEMBL1670128;VQSACDGRYKNYRN-UHFFFAOYSA-N;DTXSID301305408;AC7136;MFCD18803968;BS-33022;SY100550;A917689

Suppliers and Price of 4-Bromo-3-fluoro-2-nitrophenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Bromo-3-fluoro-2-nitrophenol
25mg
$ 105.00

Crysdot
4-Bromo-3-fluoro-2-nitrophenol 95+%
1g
$ 564.00

Chemenu
4-Bromo-3-fluoro-2-nitrophenol 95%
5g
$ 773.00

Chemcia Scientific
4-Bromo-3-fluoro-2-nitro-phenol 95%
2.5 G
$ 720.00

AK Scientific
4-Bromo-3-fluoro-2-nitrophenol
5g
$ 998.00

Total 3 raw suppliers

Chemical Property of 4-Bromo-3-fluoro-2-nitrophenol

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:234.92803
Heavy Atom Count:12
Complexity:186

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-3-fluoro-2-nitrophenol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C(=C1O)[N+](=O)[O-])F)Br

Technology Process of 4-Bromo-3-fluoro-2-nitrophenol

There total 1 articles about 4-Bromo-3-fluoro-2-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 385-01-3
2-nitro-3-fluorophenol

: 889939-22-4
4-bromo-3-fluoro-2-nitrophenol

Guidance literature:: With N-Bromosuccinimide; sulfuric acid; at 65 ℃;

Reference yield:

: ethyl 1-hydroxycyclopropane-1-carboxylate

: 889939-22-4
4-bromo-3-fluoro-2-nitrophenol

: ethyl 1-(4-bromo-2-nitrophenoxy)cyclopropanecarboxylate

Guidance literature:: ethyl 1-hydroxycyclopropane-1-carboxylate; With 15-crown-5; sodium hydride; In tetrahydrofuran; mineral oil; for 0.166667h; Inert atmosphere;

4-bromo-3-fluoro-2-nitrophenol; In tetrahydrofuran; mineral oil; at 20 ℃;

Reference yield:

: 889939-22-4
4-bromo-3-fluoro-2-nitrophenol

: 1291094-52-4
(2S,3R,4R,5S,6R)-2-[4-chloro-3-(spiro[3,4-dihydro-1,4-benzoxazine-2,1'-cyclopropane]-6-ylmethyl)phenyl]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride; 15-crown-5 / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere

1.2: 20 °C

2.1: acetic acid; iron / 3 h / 20 - 60 °C

3.1: borane-THF / tetrahydrofuran / 6 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C

5.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

5.2: 1 h / -78 °C

6.1: trifluoromethylsulfonic anhydride; trifluoroacetic acid; triethylsilane / 0.25 h / 50 °C

7.1: n-butyllithium / toluene; tetrahydrofuran; hexanes / 0.5 h / -78 °C

7.2: 0.67 h / -78 °C

7.3: 0.33 h / 20 °C

8.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 4 h / -5 - 0 °C

9.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethyl acetate; water; methanol / 2 h

With hydrogenchloride; triethylsilane; n-butyllithium; borane-THF; 15-crown-5; trifluoromethylsulfonic anhydride; boron trifluoride diethyl etherate; hydrogen; iron; sodium hydride; potassium carbonate; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexanes; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;