(1S,2S)-2-phenyl-cyclopropanecarboxylic acid {(R)-1-[4-(2-ethyl-butoxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}amide

Base Information

Chemical Name:(1S,2S)-2-phenyl-cyclopropanecarboxylic acid {(R)-1-[4-(2-ethyl-butoxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}amide
CAS No.:1286280-29-2
Molecular Formula:C₂₅H₃₃NO₄
Molecular Weight:411.541
Hs Code.:

Synonyms:(1S,2S)-2-phenyl-cyclopropanecarboxylic acid {(R)-1-[4-(2-ethyl-butoxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}amide

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Chemical Property of (1S,2S)-2-phenyl-cyclopropanecarboxylic acid {(R)-1-[4-(2-ethyl-butoxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}amide

Chemical Property:

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Technology Process of (1S,2S)-2-phenyl-cyclopropanecarboxylic acid {(R)-1-[4-(2-ethyl-butoxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}amide

There total 7 articles about (1S,2S)-2-phenyl-cyclopropanecarboxylic acid {(R)-1-[4-(2-ethyl-butoxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₂₅NO₃*ClH

: 78738-39-3
trans-2-phenyl-1-cyclopropanecarbonyl chloride

: 1286280-29-2
(1S,2S)-2-phenyl-cyclopropanecarboxylic acid {(R)-1-[4-(2-ethyl-butoxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 58026-14-5
4-(benzyloxy)-2-methoxybenzaldehyde

: 1286280-29-2
(1S,2S)-2-phenyl-cyclopropanecarboxylic acid {(R)-1-[4-(2-ethyl-butoxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 °C

1.2: 2 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; tert-butylhypochlorite / propan-1-ol / 0.13 h / 20 °C

2.2: 0.13 h / Cooling with ice

2.3: 1.5 h / 0 °C

3.1: hydrogen / palladium on carbon / methanol / 760.05 Torr

4.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 0 - 20 °C

6.1: triethylamine / dichloromethane / 1.5 h / 20 °C

With hydrogenchloride; n-butyllithium; tert-butylhypochlorite; hydrogen; potassium carbonate; triethylamine; sodium hydroxide; palladium on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; propan-1-ol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1286280-48-5
[(R)-1-(4-benzyloxy-2-methoxy-phenyl)-2-hydroxy-ethyl]carbamic acid tert-butyl ester

: 1286280-29-2
(1S,2S)-2-phenyl-cyclopropanecarboxylic acid {(R)-1-[4-(2-ethyl-butoxy)-2-methoxy-phenyl]-2-hydroxy-ethyl}amide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on carbon / methanol / 760.05 Torr

2: potassium carbonate / N,N-dimethyl-formamide / 60 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 0 - 20 °C

4: triethylamine / dichloromethane / 1.5 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; triethylamine; palladium on carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;