sodium 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoic acid

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Chemical Name:sodium 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoic acid
CAS No.:1354903-79-9
Molecular Formula:C₃₄H₂₆FN₄O₆*Na
Molecular Weight:628.592
Hs Code.:

Synonyms:sodium 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoic acid

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Chemical Property of sodium 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoic acid

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Technology Process of sodium 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoic acid

There total 12 articles about sodium 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 274-47-5
imidazo[1,5-a]pyridine

: 1354903-79-9
sodium 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 1,2-dichloro-ethane / 4.5 h / 0 - 20 °C / Inert atmosphere

1.2: 20 - 80 °C / Inert atmosphere

2.1: N-Bromosuccinimide / dichloromethane / 2.5 h / Inert atmosphere

3.1: 1,4-dioxane / 5 h / 20 °C / Inert atmosphere; Reflux

3.2: 3 h / 20 °C / Reflux

4.1: sodium hydroxide; water / methanol / 2 h / Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

6.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one; water / 0.25 h / 120 °C / Microwave irradiation

7.1: water; lithium hydroxide / tnert-amyl alcohol / 3 h / Reflux

7.2: 20 °C

With potassium phosphate; N-Bromosuccinimide; water; caesium carbonate; triethylamine; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; tnert-amyl alcohol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 6.1: Suzuki Coupling;

Reference yield:

: 1354904-91-8
methyl 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoate

: 1354903-79-9
sodium 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoic acid

Guidance literature:: methyl 3-[3-({3-[2-(4-fluorophenoxy)ethyl]-1-propyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl}carbonyl)imidazo[1,5-a]pyridin-1-yl]benzoate; With water; lithium hydroxide; In tnert-amyl alcohol; for 3h; Reflux;

With hydrogenchloride; In water; at 20 ℃;

With sodium hydroxide; In water;