(1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane

Base Information

Chemical Name:(1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane
CAS No.:114647-28-8
Molecular Formula:C₂₅H₃₂O₃Si
Molecular Weight:408.613
Hs Code.:

Synonyms:(1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane

Suppliers and Price of (1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane

There total 8 articles about (1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114647-27-7
(1R,5S,6S,7R)-3,3-ethylenedioxy-6-(tert-butyldiphenylsilyloxymethyl)-7-(tetrahydropyran-2-yl)oxybicyclo<3.3.0>octane

: 114647-28-8
(1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane

Guidance literature:: With water; acetic acid; In tetrahydrofuran; at 90 ℃; for 1.5h; Yield given;
DOI:10.1016/S0040-4020(88)90019-1

Reference yield:

: 70871-22-6
(1S,2R,3R,5R)-2-hydroxymethyl-3-(tetrahydropyran-2-yl)oxy-7,7-ethylenedioxybicyclo<3.3.0>octane

: 114647-28-8
(1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane

Guidance literature:: Multi-step reaction with 2 steps

1: 17.8 g / imidazole / dimethylformamide / 1 h / Ambient temperature

2: 0.982 g / AcOH / tetrahydrofuran; H₂O / 7 h / 45 - 50 °C

With 1H-imidazole; acetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.4000

Reference yield:

: 70870-94-9
(1S,2R,3R,5R)-2-ethoxycarbonyl-7,7-ethylenedioxy-3-hydroxy-bicyclo<3.3.0>octane

: 114647-28-8
(1R,5S,6S,7R)-3-oxo-6-(tert-butyldiphenylsilyloxymethyl)-7-hydroxybicyclo<3.3.0>octane

Guidance literature:: Multi-step reaction with 4 steps

1: PPTS

2: LAH

3: imidazole / dimethylformamide / 0.5 h / Ambient temperature

4: AcOH, H₂O / tetrahydrofuran / 1.5 h / 90 °C

With 1H-imidazole; lithium aluminium tetrahydride; water; pyridinium p-toluenesulfonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(88)90019-1