N-[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-5-nitro-pyrimidine-4,6-diamine

Base Information

Chemical Name:N-[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-5-nitro-pyrimidine-4,6-diamine
CAS No.:129659-21-8
Molecular Formula:C₂₉H₃₇N₅O₅Si
Molecular Weight:563.729
Hs Code.:

Synonyms:N-[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-5-nitro-pyrimidine-4,6-diamine

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Chemical Property of N-[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-5-nitro-pyrimidine-4,6-diamine

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Technology Process of N-[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-5-nitro-pyrimidine-4,6-diamine

There total 4 articles about N-[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-5-nitro-pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 129659-20-7
[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-(6-chloro-5-nitro-pyrimidin-4-yl)-amine

: 129659-21-8
N-[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-5-nitro-pyrimidine-4,6-diamine

Guidance literature:: With ammonia; In methanol; for 18h; Ambient temperature;
DOI:10.1016/S0040-4039(00)94392-2

Reference yield:

: 129659-18-3
(1S,2S,3S,5R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-6-oxa-bicyclo[3.1.0]hexan-2-ol

: 129659-21-8
N-[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-5-nitro-pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaN₃, NH₄Cl 2) p-TsOH / 1) DMF, 100 deg C, 4d 2) 24h, room temperature

2: H₂ / Lindlar cat. / methanol

3: Et₃N / CH₂Cl₂

4: 86 percent / NH₃ / methanol / 18 h / Ambient temperature

With sodium azide; ammonia; hydrogen; ammonium chloride; toluene-4-sulfonic acid; triethylamine; Lindlar catalyst; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)94392-2

Reference yield:

: 129659-17-2
(1R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopent-2-enol

: 129659-21-8
N-[(3aR,4S,6S,6aS)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl]-5-nitro-pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / m-chloroperbenzoic acid

2: 1) NaN₃, NH₄Cl 2) p-TsOH / 1) DMF, 100 deg C, 4d 2) 24h, room temperature

3: H₂ / Lindlar cat. / methanol

4: Et₃N / CH₂Cl₂

5: 86 percent / NH₃ / methanol / 18 h / Ambient temperature

With sodium azide; ammonia; hydrogen; ammonium chloride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; Lindlar catalyst; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)94392-2