2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid

Base Information

Chemical Name:2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid
CAS No.:103504-07-0
Molecular Formula:C₂₃H₃₆N₄O₇S
Molecular Weight:512.627
Hs Code.:

Synonyms:2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid

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Chemical Property of 2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid

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Technology Process of 2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid

There total 9 articles about 2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 103991-28-2
Tosyl-(α-methylalanyl)(3)-α-methylalanin-methylester

: 103504-07-0
2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 50 ℃;
DOI:10.1039/d0ce01267j

Reference yield:

: methyl 2-methyl-N-p-toluenesulfonyl alaninate

: 103504-07-0
2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere

7: lithium hydroxide monohydrate / tetrahydrofuran; water / 50 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/d0ce01267j

Reference yield:

: 67706-12-1
Tosyl-α-methyl-alanyl-α-methylalanin-methylester

: 103504-07-0
2-methyl-2-(2-methyl-2-{2-methyl-2-[2-methyl-2-(toluene-4-sulfonylamino)-propionylamino]-propionylamino}-propionylamino)-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere

5: lithium hydroxide monohydrate / tetrahydrofuran; water / 50 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1039/d0ce01267j