ethyl 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate

Base Information

• Chemical Name: ethyl 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate
• CAS No.: 123044-13-3
• Molecular Formula: C₁₄H₁₆N₂O₂S
• Molecular Weight: 276.359
• Mol file: 123044-13-3.mol

Synonyms:ethyl 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate

Chemical Property of ethyl 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate

There total 2 articles about ethyl 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-benzylidene acetoacetate (620-80-4) + thiourea (17356-08-0) → ethyl 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate (123044-13-3)

Guidance literature:

With hydrogenchloride; sodium hydroxide; Yield given. Multistep reaction; 1.) MeOH, reflux, 2.) H₂O;

DOI:10.1021/jo971010u

Reference yield:

2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylic acid ethyl ester hydrochloride (123044-26-8) → ethyl 2-imino-4-methyl-6-phenyl-3,6-dihydro-2H-1,3-thiazine-5-carboxylate (123044-13-3)

Guidance literature:

With sodium hydroxide; In ethanol; water;

DOI:10.1080/10426500701752903

Reference yield: 68.0%

ethyl 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylate (123044-13-3) → 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione (123043-88-9,33458-26-3)

Guidance literature:

In toluene; at 220 ℃; for 0.5h; microwave irradiation;

DOI:10.1021/jo060692v

upstream raw materials:

ethyl 2-benzylidene acetoacetate

thiourea

2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylic acid ethyl ester hydrochloride

Downstream raw materials:

5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione