N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine

Base Information

• Chemical Name: N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine
• CAS No.: 1355045-43-0
• Molecular Formula: C₁₉H₂₅N₃
• Molecular Weight: 295.428
• Mol file: 1355045-43-0.mol

Synonyms:N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine

Chemical Property of N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine

There total 2 articles about N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

piperidine (110-89-4) + N-(2,4,6-trimethylphenyl)-(6-chloropyridin-2-yl)amine (1355045-48-5) → N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine (1355045-43-0)

Guidance literature:

In toluene; at 160 ℃; for 72h;

DOI:10.1002/ejic.201100843

Reference yield:

2,4,6-trimethylaniline (88-05-1) → N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine (1355045-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert-Amyl alcohol; sodium hydride / tetrahydrofuran / 2 h / 65 °C

1.2: 2 h / 65 °C

1.3: 2 h / Reflux

2.1: toluene / 72 h / 160 °C

With tert-Amyl alcohol; sodium hydride; In tetrahydrofuran; toluene;

DOI:10.1002/ejic.201100843

Reference yield: 80.0%

N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine (1355045-43-0) + tetra(benzyl)hafnium (31406-67-4) → (C6H5CH2)3Hf(C5H3N(N(CH2)5)NC6H2(CH3)3) (1369385-18-1)

Guidance literature:

In toluene; in Schlenk glassware or N2-filled glovebox; soln. of aminopyridine deriv. in toluene added to Hf(CH2Ph)4 in toluene; stirred for 12 h at room temp.; toluene removed in vac.; residue extd. with hexane; vol. of extract reduced; crystd. at -24°C; elem. anal.;

DOI:10.1002/zaac.201100475

upstream raw materials:

piperidine

N-(2,4,6-trimethylphenyl)-(6-chloropyridin-2-yl)amine

2,4,6-trimethylaniline

Downstream raw materials:

[TiCl₂(NEt₂)(N-(2,4,6-trimethylphenyl)-6-(piperidin-1-yl)pyridin-2-amine(-H))]

(C₆H₅CH₂)3Hf(C₅H₃N(N(CH₂)5)NC₆H₂(CH₃)3)