2-amino-6-(2,4-dichlorobenzyl)-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one

Base Information

• Chemical Name: 2-amino-6-(2,4-dichlorobenzyl)-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one
• CAS No.: 651358-48-4
• Molecular Formula: C₁₃H₁₀Cl₂N₄O
• Molecular Weight: 309.155

Synonyms:2-amino-6-(2,4-dichlorobenzyl)-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one

Chemical Property of 2-amino-6-(2,4-dichlorobenzyl)-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one

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Technology Process of 2-amino-6-(2,4-dichlorobenzyl)-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one

There total 6 articles about 2-amino-6-(2,4-dichlorobenzyl)-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,6-diamino-3H-pyrimidin-4-one (100643-27-4,143504-99-8) + 1-chloro-3-(2,4-dichloro-phenyl)-propan-2-one (90273-68-0) → 2-amino-6-(2,4-dichlorobenzyl)-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one (651358-48-4)

Guidance literature:

2,6-diamino-3H-pyrimidin-4-one; With water; sodium acetate; In diethyl ether; for 0.333333h; Reflux;

1-chloro-3-(2,4-dichloro-phenyl)-propan-2-one; In methanol; for 12h; regiospecific reaction; Reflux;

DOI:10.1016/j.bmc.2010.03.052

Reference yield: 56.0%

2,6-diamino-3H-pyrimidin-4-one (100643-27-4,143504-99-8) + α-bromomethyl-(2,4-dichlorobenzyl)ketone (651358-40-6) → 2-amino-6-(2,4-dichlorobenzyl)-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one (651358-48-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1016/j.bmc.2003.08.034

Reference yield: 44.0%

2,6-diamino-3H-pyrimidin-4-one (100643-27-4,143504-99-8) + α-bromomethyl-(2,4-dichlorobenzyl)ketone (651358-40-6) → 1-(2,6-diamino-pyrimidin-4-yloxy)-3-(2,4-dichlorophenyl)-propan-2-one (1234201-45-6) + 2-amino-6-(2,4-dichlorobenzyl)-3,7-dihydro-4H-pyrrolo-[2,3-d]pyrimidin-4-one (651358-48-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1016/j.bmc.2010.03.052

upstream raw materials:

2,6-diamino-3H-pyrimidin-4-one

α-bromomethyl-(2,4-dichlorobenzyl)ketone

2,4-dichlorophenylacetic acid

2,4-dichlorophenylacetyl chloride

Downstream raw materials:

2-amino-4-chloro-6-(2,4-dichlorobenzyl)-pyrrolo[2,3-d]pyrimidine

C₁₈H₁₈Cl₂N₄O₂

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