Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate

Base Information

• Chemical Name: Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate
• CAS No.: 118111-61-8
• Molecular Formula: C₃₀H₃₄N₄O₇
• Molecular Weight: 562.623

Synonyms:Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate

Chemical Property of Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate

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Technology Process of Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate

There total 2 articles about Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate (76858-72-5) + 6-(Bromomethyl)-2,4-dimethoxyquinazoline (112888-62-7) → Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate (118111-61-8)

Guidance literature:

With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 70 ℃;

DOI:10.1021/jm00123a010

Reference yield:

2,4-Dimethoxy-6-methylquinazoline (92316-82-0) → Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate (118111-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

2: 29 percent / 2,6-lutidine / dimethylformamide / 70 °C

With 2,6-dimethylpyridine; N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a010

Reference yield: 88.0%

Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate (118111-61-8) → N-p-[N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoyl-L-glutamic acid (112887-72-6)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 60 ℃; for 14.5h;

DOI:10.1021/jm00123a010

upstream raw materials:

diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate

6-(Bromomethyl)-2,4-dimethoxyquinazoline

2,4-Dimethoxy-6-methylquinazoline

Downstream raw materials:

N-p-[N-(3,4-dihydro-2-methoxy-4-oxoquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoyl-L-glutamic acid

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