5-(2-Benzyloxy-4,6-dichloro-phenyl)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester

Base Information

Chemical Name:5-(2-Benzyloxy-4,6-dichloro-phenyl)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester
CAS No.:125443-03-0
Molecular Formula:C₂₀H₂₀Cl₂F₂O₄
Molecular Weight:433.279
Hs Code.:

Synonyms:5-(2-Benzyloxy-4,6-dichloro-phenyl)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-Benzyloxy-4,6-dichloro-phenyl)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester

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Technology Process of 5-(2-Benzyloxy-4,6-dichloro-phenyl)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester

There total 3 articles about 5-(2-Benzyloxy-4,6-dichloro-phenyl)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 124082-53-7
3-(2-benzyloxy-4,6-dichlorophenyl)propionaldehyde

: 125443-03-0
5-(2-Benzyloxy-4,6-dichloro-phenyl)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester

Guidance literature:: With zinc; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)88466-X

Reference yield:

: 125442-89-9
1-Benzyloxy-2-bromomethyl-3,5-dichloro-benzene

: 125443-03-0
5-(2-Benzyloxy-4,6-dichloro-phenyl)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / LDA / tetrahydrofuran / -78 °C

2: 83 percent / DIBAL / toluene / -78 °C

3: 70 percent / Zn / tetrahydrofuran

With diisobutylaluminium hydride; zinc; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(00)88466-X

Reference yield:

: 3-(2-Benzyloxy-4,6-dichloro-phenyl)-propionic acid tert-butyl ester

: 125443-03-0
5-(2-Benzyloxy-4,6-dichloro-phenyl)-2,2-difluoro-3-hydroxy-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / DIBAL / toluene / -78 °C

2: 70 percent / Zn / tetrahydrofuran

With diisobutylaluminium hydride; zinc; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(00)88466-X