N-{2-[4-(2-Azido-phenyl)-8-oxo-5,6,7,8-tetrahydro-quinolin-6-yl]-ethyl}-acetamide

Base Information

Chemical Name:N-{2-[4-(2-Azido-phenyl)-8-oxo-5,6,7,8-tetrahydro-quinolin-6-yl]-ethyl}-acetamide
CAS No.:165675-06-9
Molecular Formula:C₁₉H₁₉N₅O₂
Molecular Weight:349.392
Hs Code.:

Synonyms:N-{2-[4-(2-Azido-phenyl)-8-oxo-5,6,7,8-tetrahydro-quinolin-6-yl]-ethyl}-acetamide

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Chemical Property of N-{2-[4-(2-Azido-phenyl)-8-oxo-5,6,7,8-tetrahydro-quinolin-6-yl]-ethyl}-acetamide

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Technology Process of N-{2-[4-(2-Azido-phenyl)-8-oxo-5,6,7,8-tetrahydro-quinolin-6-yl]-ethyl}-acetamide

There total 6 articles about N-{2-[4-(2-Azido-phenyl)-8-oxo-5,6,7,8-tetrahydro-quinolin-6-yl]-ethyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 165675-05-8
N-(2-{4-(2-Azido-phenyl)-8-[1-(2-azido-phenyl)-meth-(E)-ylidene]-5,6,7,8-tetrahydro-quinolin-6-yl}-ethyl)-acetamide

: 165675-06-9
N-{2-[4-(2-Azido-phenyl)-8-oxo-5,6,7,8-tetrahydro-quinolin-6-yl]-ethyl}-acetamide

Guidance literature:: With ozone; In methanol; dichloromethane; at -78 ℃;
DOI:10.1021/ja00155a010

Reference yield:

: 128350-17-4
2,6-bis(2-azidobenzylidene)-4-(2-hydroxyethyl)cyclohexanone

: 165675-06-9
N-{2-[4-(2-Azido-phenyl)-8-oxo-5,6,7,8-tetrahydro-quinolin-6-yl]-ethyl}-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / Yb(fod)3 / CH₂Cl₂ / Heating

3: 100 percent / NaH / dimethylformamide / 2 h / 0 - 20 °C

4: 62 percent / hydroxylaminy hydrochloride / acetonitrile / 7 h / Heating

5: 67 percent / O₃ / CH₂Cl₂; methanol / -78 °C

With tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)ytterbium; hydroxylamine hydrochloride; sodium hydride; ozone; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00155a010

Reference yield:

: 172330-57-3
Methanesulfonic acid 2-{3,5-bis-[1-(2-azido-phenyl)-meth-(E)-ylidene]-4-oxo-cyclohexyl}-ethyl ester

: 165675-06-9
N-{2-[4-(2-Azido-phenyl)-8-oxo-5,6,7,8-tetrahydro-quinolin-6-yl]-ethyl}-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Yb(fod)3 / CH₂Cl₂ / Heating

2: 100 percent / NaH / dimethylformamide / 2 h / 0 - 20 °C

3: 62 percent / hydroxylaminy hydrochloride / acetonitrile / 7 h / Heating

4: 67 percent / O₃ / CH₂Cl₂; methanol / -78 °C

With tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)ytterbium; hydroxylamine hydrochloride; sodium hydride; ozone; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00155a010