ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(1H-pyrazol-1-yl)phenyl]butanoate

Base Information

Chemical Name:ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(1H-pyrazol-1-yl)phenyl]butanoate
CAS No.:1289627-09-3
Molecular Formula:C₁₇H₂₂N₂O₄S
Molecular Weight:350.439
Hs Code.:

Synonyms:ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(1H-pyrazol-1-yl)phenyl]butanoate

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Chemical Property of ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(1H-pyrazol-1-yl)phenyl]butanoate

Chemical Property:

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Technology Process of ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(1H-pyrazol-1-yl)phenyl]butanoate

There total 7 articles about ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(1H-pyrazol-1-yl)phenyl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-13-1
NH-pyrazole

: 1289627-00-4
{4-[4-ethoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl]phenyl}boronic acid

: 1289627-09-3
ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(1H-pyrazol-1-yl)phenyl]butanoate

Guidance literature:: With pyridine; copper diacetate; In dichloromethane; at 20 - 25 ℃; for 48h;

Reference yield:

: 535-13-7
2-chloro-propanoic acid, ethyl ester

: 1289627-09-3
ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(1H-pyrazol-1-yl)phenyl]butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 20 h / 77 °C

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / Reflux

4: sodium periodate; ammonium acetate / water; acetone / 20 - 25 °C

5: pyridine / copper diacetate / dichloromethane / 48 h / 20 - 25 °C

With pyridine; sodium periodate; ammonium acetate; potassium acetate; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper diacetate; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 4654-39-1
4-bromophenethanol

: 1289627-09-3
ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(1H-pyrazol-1-yl)phenyl]butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 1 h / 0 - 25 °C

2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / Reflux

4: sodium periodate; ammonium acetate / water; acetone / 20 - 25 °C

5: pyridine / copper diacetate / dichloromethane / 48 h / 20 - 25 °C

With pyridine; 1H-imidazole; sodium periodate; ammonium acetate; iodine; potassium acetate; caesium carbonate; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper diacetate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;