Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide

Base Information

• Chemical Name: Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide
• CAS No.: 1027546-78-6
• Molecular Formula: C₂₅H₂₄N₄O₄S
• Molecular Weight: 476.556

Synonyms:Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide

Chemical Property of Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide

Chemical Property:

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Technology Process of Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide

There total 5 articles about Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Naphthalenesulfonyl chloride (93-11-8) → Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide (1027546-78-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / N-methylmorpholine / dioxane; ethyl acetate / 16 h / Ambient temperature

2: 92 percent / 1N aq. HCl, AcOH / 2 h / Heating

3: SOCl₂ / 1 h / Heating

4: tetrahydrofuran / 1 h

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; acetic acid; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

DOI:10.1021/jm960668h

Reference yield:

(S)-3-(3-cyanophenyl)-2-(naphthalene-2-sulfonamido)propanoic acid (144831-77-6) → Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide (1027546-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: tetrahydrofuran / 1 h

With thionyl chloride; In tetrahydrofuran;

DOI:10.1021/jm960668h

Reference yield:

methyl (S)-3-(3-cyanophenyl)-2-(naphthalene-2-sulfonamido)propanoate (194085-41-1) → Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide (1027546-78-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / 1N aq. HCl, AcOH / 2 h / Heating

2: SOCl₂ / 1 h / Heating

3: tetrahydrofuran / 1 h

With hydrogenchloride; thionyl chloride; acetic acid; In tetrahydrofuran;

DOI:10.1021/jm960668h

upstream raw materials:

piperazine-1-carbaldehyde

N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl chloride

2-Naphthalenesulfonyl chloride

(S)-3-(3-cyanophenyl)-2-(naphthalene-2-sulfonamido)propanoic acid

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