2,2,2-trichloroethyl 5-(5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)pentanoate

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Chemical Name:2,2,2-trichloroethyl 5-(5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)pentanoate
CAS No.:550355-96-9
Molecular Formula:C₂₄H₃₁Cl₃N₂O₈
Molecular Weight:581.878
Hs Code.:

Synonyms:2,2,2-trichloroethyl 5-(5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)pentanoate

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Chemical Property of 2,2,2-trichloroethyl 5-(5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)pentanoate

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Technology Process of 2,2,2-trichloroethyl 5-(5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)pentanoate

There total 7 articles about 2,2,2-trichloroethyl 5-(5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 68726-90-9
2',2',2'-trichloroethyl 5-bromopentanoate

: 550355-92-5
allyl 5-hydroxy-2-{[(S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-4-methoxyphenylcarbamate

: 550355-96-9
2,2,2-trichloroethyl 5-(5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)pentanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm020526p

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 550355-96-9
2,2,2-trichloroethyl 5-(5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: (COCl)2 / dimethylformamide

2: K₂CO₃

3: H₂ / Pd/C / methanol / 0.92 h / 2585.74 Torr

4: 85 percent / pyridine / tetrahydrofuran / 0.17 h / -78 °C

5: 88 percent / K₂CO₃ / dimethylformamide / 20 °C

With pyridine; oxalyl dichloride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020526p

Reference yield:

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 550355-96-9
2,2,2-trichloroethyl 5-(5-{[(allyloxy)carbonyl]amino}-4-{[(2S)-2-(hydroxymethyl)pyrrolidinyl]carbonyl}-2-methoxyphenoxy)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃

2: H₂ / Pd/C / methanol / 0.92 h / 2585.74 Torr

3: 85 percent / pyridine / tetrahydrofuran / 0.17 h / -78 °C

4: 88 percent / K₂CO₃ / dimethylformamide / 20 °C

With pyridine; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020526p