3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine

Base Information

Chemical Name:3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine
CAS No.:1308869-18-2
Molecular Formula:C₂₈H₃₂N₄
Molecular Weight:424.589
Hs Code.:

Synonyms:3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine

Suppliers and Price of 3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine

There total 14 articles about 3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₀N₄O

: 1308869-18-2
3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine

Guidance literature:: C₃₆H₄₀N₄O; With trifluoroacetic acid; at 70 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1308869-18-2
3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichlorophosphate / Cooling with ice; Sealed tube; Inert atmosphere

1.2: 48.5 h / 75 °C

1.3: Cooling with ice

2.1: ethanol; sodium tetrahydroborate / 0.67 h / 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 2.5 h / 20 °C

4.1: toluene / 12 h / Reflux

5.1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 2.5 h / 60 °C

6.1: 1-methyl-pyrrolidin-2-one / 0.5 h / 150 °C / Microwave irradiation

7.1: potassium acetate / palladium catalyst / ethanol; water / 2 h / 70 °C

8.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 3102.97 Torr

9.1: trifluoroacetic acid / 1 h / 70 °C

With sodium tetrahydroborate; thionyl chloride; ethanol; hydrogen; potassium acetate; trifluoroacetic acid; trichlorophosphate; N,N,N',N'-tetramethylguanidine; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1308869-73-9
1-(6-neopentylpyrimidin-4-yl)ethanone

: 1308869-18-2
3-(2-(6-neopentylpyrimidin-4-yl)propyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 2.5 h / 60 °C

2: 1-methyl-pyrrolidin-2-one / 0.5 h / 150 °C / Microwave irradiation

3: potassium acetate / palladium catalyst / ethanol; water / 2 h / 70 °C

4: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 3102.97 Torr

5: trifluoroacetic acid / 1 h / 70 °C

With hydrogen; potassium acetate; trifluoroacetic acid; N,N,N',N'-tetramethylguanidine; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water;