6-(2,4-Dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid

Base Information

Chemical Name:6-(2,4-Dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid
CAS No.:141263-54-9
Molecular Formula:C₁₂H₁₇Cl₂O₅P
Molecular Weight:343.144
Hs Code.:
DSSTox Substance ID:DTXSID10161616
Wikidata:Q76149886
Mol file:141263-54-9.mol

Synonyms:6-(2,4-dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid;DCPHHP

Suppliers and Price of 6-(2,4-Dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 6-(2,4-Dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid

Chemical Property:

Vapor Pressure:5.12E-15mmHg at 25°C
Boiling Point:595.3°Cat760mmHg
Flash Point:313.8°C
PSA：107.80000
Density:1.51g/cm³
LogP:2.21560
XLogP3:1.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:342.0190660
Heavy Atom Count:20
Complexity:338

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1Cl)Cl)CCC(CC(CP(=O)(O)O)O)O
Isomeric SMILES:C1=CC(=C(C=C1Cl)Cl)CC[C@H](C[C@H](CP(=O)(O)O)O)O

Technology Process of 6-(2,4-Dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid

There total 9 articles about 6-(2,4-Dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101910-02-5,101910-03-6,141263-55-0
(3R,5R)-5-[2-(2,4-Dichloro-phenyl)-ethyl]-tetrahydro-furan-2,3-diol

: 141263-54-9
6-(2,4-Dichlorophenyl)-D-erythro-2,4-dihydroxyhexylphosphonic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 95.6 percent / NaBH₄ / ethanol / 1 h / 0 °C

2: 78.8 percent / pyridine / 3 h / Ambient temperature

3: 89.5 percent / p-toluenesulfonic acid, 2-methoxypropene / 0.67 h / 20 °C

4: 95 percent / Bu₄NF / tetrahydrofuran / 0.67 h / 20 °C

5: 76.6 percent / triphenylphosphine, N-bromosuccinimide / CH₂Cl₂ / 0.67 h / Heating

6: 78 percent / 30 h / Heating

7: NaI / acetonitrile / 3 h / 60 °C

8: Varion KS (H⁺) resin / H₂O

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; 2-Methoxypropene; Varion KS (H⁺) resin; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triphenylphosphine; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0008-6215(00)90500-7

Reference yield:

: 141263-67-4
6-(2,4-Dichlorophenyl)-2,4-O-isopropylidene-D-erythro-1,2,4-hexanetriol

: 141263-54-9
6-(2,4-Dichlorophenyl)-D-erythro-2,4-dihydroxyhexylphosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 76.6 percent / triphenylphosphine, N-bromosuccinimide / CH₂Cl₂ / 0.67 h / Heating

2: 78 percent / 30 h / Heating

3: NaI / acetonitrile / 3 h / 60 °C

4: Varion KS (H⁺) resin / H₂O

With N-Bromosuccinimide; Varion KS (H⁺) resin; triphenylphosphine; sodium iodide; In dichloromethane; water; acetonitrile;
DOI:10.1016/S0008-6215(00)90500-7

Reference yield:

: 141263-56-1
6-(2,4-Dichlorophenyl)-D-erythro-1,2,4-hexanetriol

: 141263-54-9
6-(2,4-Dichlorophenyl)-D-erythro-2,4-dihydroxyhexylphosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 78.8 percent / pyridine / 3 h / Ambient temperature

2: 89.5 percent / p-toluenesulfonic acid, 2-methoxypropene / 0.67 h / 20 °C

3: 95 percent / Bu₄NF / tetrahydrofuran / 0.67 h / 20 °C

4: 76.6 percent / triphenylphosphine, N-bromosuccinimide / CH₂Cl₂ / 0.67 h / Heating

5: 78 percent / 30 h / Heating

6: NaI / acetonitrile / 3 h / 60 °C

7: Varion KS (H⁺) resin / H₂O

With pyridine; N-Bromosuccinimide; 2-Methoxypropene; Varion KS (H⁺) resin; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triphenylphosphine; sodium iodide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/S0008-6215(00)90500-7