(1R)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine

Base Information

• Chemical Name: (1R)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine
• CAS No.: 1123309-24-9
• Molecular Formula: C₂₇H₂₉N
• Molecular Weight: 367.534
• Mol file: 1123309-24-9.mol

Synonyms:(1R)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine

Chemical Property of (1R)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (1R)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine

There total 2 articles about (1R)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-tert-Butylbenzaldehyde (939-97-9) + N-(1,1-diphenyl-3-butenyl)amine (356762-89-5) → (1S)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine + (1R)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine (1123309-24-9)

Guidance literature:

With (R)-3,3'-bis-(2-naphthyl)octahydrobinol; In tert-butyl methyl ether; at 50 ℃; for 48h; optical yield given as %ee; enantioselective reaction; Molecular sieve;

DOI:10.1002/anie.200803610

Reference yield:

allyl (E)-2-((4-(tert-butyl)benzylidene)amino)-2,2-diphenylacetate → (1S)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine + (1R)-1-(4-tert-butylphenyl)-N-(diphenylmethylene)but-3-en-1-amine (1123309-24-9) + C27H29N

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis[(S)-4,5-dihydro-3H-binaphtho[2,1-c:1',2'-e]phosphino]ferrocene; In dimethyl sulfoxide; at 25 ℃; for 24h; Overall yield = 88 %; Overall yield = 75 mg; enantioselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.8b00491

upstream raw materials:

4-tert-Butylbenzaldehyde

N-(1,1-diphenyl-3-butenyl)amine