(2S)-2-benzyl-oxirane-[N-quinoline-2-amine-1-yl]-2-carboxylic acid amide

Base Information

Chemical Name:(2S)-2-benzyl-oxirane-[N-quinoline-2-amine-1-yl]-2-carboxylic acid amide
CAS No.:910539-82-1
Molecular Formula:C₁₉H₁₆N₂O₂
Molecular Weight:304.348
Hs Code.:

Synonyms:(2S)-2-benzyl-oxirane-[N-quinoline-2-amine-1-yl]-2-carboxylic acid amide

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Chemical Property of (2S)-2-benzyl-oxirane-[N-quinoline-2-amine-1-yl]-2-carboxylic acid amide

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Technology Process of (2S)-2-benzyl-oxirane-[N-quinoline-2-amine-1-yl]-2-carboxylic acid amide

There total 5 articles about (2S)-2-benzyl-oxirane-[N-quinoline-2-amine-1-yl]-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 910539-51-4
(2S)-2-benzyl-oxirane-2-carboxylic acid

: 580-22-3
2-aminoquinoline

: 910539-82-1
(2S)-2-benzyl-oxirane-[N-quinoline-2-amine-1-yl]-2-carboxylic acid amide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1039/b606859f

Reference yield:

: 910539-47-8
2-benzyl-acrylic acid [(S)-1-ethoxycarbonyl-ethyl]ester

: 910539-82-1
(2S)-2-benzyl-oxirane-[N-quinoline-2-amine-1-yl]-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: 3.27 g / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 24 h / Heating

2: 100 percent / NaOH / tetrahydrofuran / 1 h / 20 °C

3: 39 percent / PyBOP; (iPr)2NH / CH₂Cl₂ / 20 °C

With sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b606859f

Reference yield:

: 910539-49-0
(2S)-2-benzyl-oxirane-2-carboxylic acid [(S)-1-ethoxycarbonyl-ethyl]ester

: 910539-82-1
(2S)-2-benzyl-oxirane-[N-quinoline-2-amine-1-yl]-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaOH / tetrahydrofuran / 1 h / 20 °C

2: 39 percent / PyBOP; (iPr)2NH / CH₂Cl₂ / 20 °C

With sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b606859f