3-(3,5-dichlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester

Base Information

Chemical Name:3-(3,5-dichlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester
CAS No.:856571-35-2
Molecular Formula:C₂₇H₂₃Cl₂N₃O₄
Molecular Weight:524.403
Hs Code.:

Synonyms:3-(3,5-dichlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester

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Chemical Property of 3-(3,5-dichlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester

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Technology Process of 3-(3,5-dichlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester

There total 4 articles about 3-(3,5-dichlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 856571-16-9
2-(2-aminobenzoylamino)-3-(3,5-dichlorophenyl)propionic acid ethyl ester

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 856571-35-2
3-(3,5-dichlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester

Guidance literature:: Indole-2-carboxylic acid; With phosphorus pentachloride; acetyl chloride; at 20 ℃; for 3h;

2-(2-aminobenzoylamino)-3-(3,5-dichlorophenyl)propionic acid ethyl ester; With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2005.01.002

Reference yield:

: 115491-81-1
2-acetylamino-2-(3,5-dichlorobenzyl)malonic acid diethyl ester

: 856571-35-2
3-(3,5-dichlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 69 percent / HCl / H₂O; dioxane / Heating

2.1: 92 percent / HCl / 0 °C

3.1: 39 percent / Et₃N / ethyl acetate / 4 h / Heating

4.1: AcCl; PCl₅ / 3 h / 20 °C

4.2: 38 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; phosphorus pentachloride; triethylamine; acetyl chloride; In 1,4-dioxane; water; ethyl acetate;
DOI:10.1016/j.ejmech.2005.01.002

Reference yield:

: 2-amino-3-(3,5-dichlorophenyl)propionic acid ethyl ester hydrochloride

: 856571-35-2
3-(3,5-dichlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 39 percent / Et₃N / ethyl acetate / 4 h / Heating

2.1: AcCl; PCl₅ / 3 h / 20 °C

2.2: 38 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With phosphorus pentachloride; triethylamine; acetyl chloride; In ethyl acetate;
DOI:10.1016/j.ejmech.2005.01.002