(R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Base Information

Chemical Name:(R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
CAS No.:1159996-53-8
Molecular Formula:C₁₈H₁₆F₃NO
Molecular Weight:319.326
Hs Code.:

Synonyms:(R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Suppliers and Price of (R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

There total 5 articles about (R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159997-92-8
(R)-(-)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

: 108-24-7
acetic anhydride

: 1159996-53-8
(R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1159997-91-7
1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline

: 108-24-7
acetic anhydride

: 1159996-53-8
(R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

: C₁₈H₁₆F₃NO

Guidance literature:: 1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline; With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₄₂H₄₆FeP₂; hydrogen bromide; hydrogen; In tetrahydrofuran; water; at 30 ℃; for 12h; under 38002.6 Torr; Schlenk technique; Autoclave;

acetic anhydride; Schlenk technique; Autoclave;
DOI:10.1021/acs.orglett.9b03251

Reference yield:

: 64-04-0
phenethylamine

: 1159996-53-8
(R)-1-(1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

: C₁₈H₁₆F₃NO

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 12 h / 0 °C / Schlenk technique

2.1: 2-chloropyridine; trifluoromethylsulfonic anhydride / dichloromethane / -78 - 20 °C / Schlenk technique

3.1: C₄₂H₄₆FeP₂; hydrogen; bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen bromide / tetrahydrofuran; water / 12 h / 30 °C / 38002.6 Torr / Schlenk technique; Autoclave

3.2: Schlenk technique; Autoclave

With 2-chloropyridine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; trifluoromethylsulfonic anhydride; C₄₂H₄₆FeP₂; hydrogen bromide; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/acs.orglett.9b03251