3-hydroxy-N-(3-isopropylphenyl)dec-4-ynamide

Base Information

• Chemical Name: 3-hydroxy-N-(3-isopropylphenyl)dec-4-ynamide
• CAS No.: 1421689-70-4
• Molecular Formula: C₁₉H₂₇NO₂
• Molecular Weight: 301.429
• Mol file: 1421689-70-4.mol

Synonyms:3-hydroxy-N-(3-isopropylphenyl)dec-4-ynamide

Chemical Property of 3-hydroxy-N-(3-isopropylphenyl)dec-4-ynamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-N-(3-isopropylphenyl)dec-4-ynamide

There total 1 articles about 3-hydroxy-N-(3-isopropylphenyl)dec-4-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

oct-2-ynal (1846-68-0) + N-(3-iso-propylphenyl)acetamide (7766-63-4) → 3-hydroxy-N-(3-isopropylphenyl)dec-4-ynamide (1421689-70-4)

Guidance literature:

N-(3-iso-propylphenyl)acetamide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -20 - 20 ℃; for 0.416667h; Inert atmosphere;

oct-2-ynal; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol303518n

Reference yield: 71.0%

3-hydroxy-N-(3-isopropylphenyl)dec-4-ynamide (1421689-70-4) → 4-(hept-1-yn-1-yl)-1-(3-isopropylphenyl)azetidin-2-one (1421689-82-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triethyl phosphite; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol303518n

Reference yield:

3-hydroxy-N-(3-isopropylphenyl)dec-4-ynamide (1421689-70-4) → 2-(hept-1-yn-1-yl)-1-(3-isopropylphenyl)azetidine (1421689-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethyl phosphite; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triethyl phosphite; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ol303518n

upstream raw materials:

oct-2-ynal

N-(3-iso-propylphenyl)acetamide

Downstream raw materials:

4-(hept-1-yn-1-yl)-1-(3-isopropylphenyl)azetidin-2-one

2-(hept-1-yn-1-yl)-1-(3-isopropylphenyl)azetidine