4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride

Base Information

Chemical Name:4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride
CAS No.:1351338-64-1
Molecular Formula:C₂₇H₃₃F₂N₇O₄*ClH
Molecular Weight:594.061
Hs Code.:

4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride

Synonyms:4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride

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Chemical Property of 4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride

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Technology Process of 4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride

There total 11 articles about 4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351341-71-3
4-(5-{2-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester

: 1351338-64-1
4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride

Guidance literature:: 4-(5-{2-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With ammonium hydroxide; In methanol; dichloromethane;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

Reference yield:

: (trans)-1-benzyl-4-(2,5-difluorophenyl)-3-nitropiperidine hydrochloride

: 1351338-64-1
4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: zinc; acetic acid / ethanol / 80 °C

2: triethylamine / water; tetrahydrofuran / 16 h / 0 - 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 80 °C / 22502.3 Torr

4: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 40 h / 80 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 1245078-65-2
[(3R,4R)-1-benzyl-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester

: 1351338-64-1
4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 80 °C / 22502.3 Torr

2: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 40 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; tert-butyl alcohol;