{3-[(4-aminomethyl-benzyl)tert-butoxycarbonyl-amino]-propyl}-cyclohexyl-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {3-[(4-aminomethyl-benzyl)tert-butoxycarbonyl-amino]-propyl}-cyclohexyl-carbamic acid tert-butyl ester
• CAS No.: 917021-06-8
• Molecular Formula: C₂₇H₄₅N₃O₄
• Molecular Weight: 475.672
• Mol file: 917021-06-8.mol

Synonyms:{3-[(4-aminomethyl-benzyl)tert-butoxycarbonyl-amino]-propyl}-cyclohexyl-carbamic acid tert-butyl ester

Chemical Property of {3-[(4-aminomethyl-benzyl)tert-butoxycarbonyl-amino]-propyl}-cyclohexyl-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {3-[(4-aminomethyl-benzyl)tert-butoxycarbonyl-amino]-propyl}-cyclohexyl-carbamic acid tert-butyl ester

There total 2 articles about {3-[(4-aminomethyl-benzyl)tert-butoxycarbonyl-amino]-propyl}-cyclohexyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C27H41N3O4 (917021-04-6) → {3-[(4-aminomethyl-benzyl)tert-butoxycarbonyl-amino]-propyl}-cyclohexyl-carbamic acid tert-butyl ester (917021-06-8)

Guidance literature:

With ammonium hydroxide; hydrogen; In tetrahydrofuran; methanol;

Reference yield:

4-cyanobenzaldehyde (105-07-7) → {3-[(4-aminomethyl-benzyl)tert-butoxycarbonyl-amino]-propyl}-cyclohexyl-carbamic acid tert-butyl ester (917021-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 6 h / 65 °C / Molecular sieve

1.2: 20 °C / Molecular sieve

2.1: sodium carbonate / tert-butyl alcohol / 20 °C

3.1: ammonium hydroxide; hydrogen / methanol; tetrahydrofuran

With ammonium hydroxide; hydrogen; sodium carbonate; In tetrahydrofuran; methanol; tert-butyl alcohol;

Reference yield: 89.0%

{3-[(4-aminomethyl-benzyl)tert-butoxycarbonyl-amino]-propyl}-cyclohexyl-carbamic acid tert-butyl ester (917021-06-8) + 2,6 dichloropurine (5451-40-1) → [3-(tert-butoxycarbonyl-cyclohexyl-amino)-propyl]-{4-[(2-chloro-9H-purin-6-ylamino)-methyl]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:

With triethylamine; In tert-butyl alcohol; at 50 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm501772w

upstream raw materials:

C₂₇H₄₁N₃O₄

4-cyanobenzaldehyde

Downstream raw materials:

C₃₄H₅₄N₆O₄

C₃₈H₅₃ClN₆O₄

C₃₇H₅₉N₇O₄

C₄₉H₆₇N₇O₄