2-(2,4-difluorobenzylthio)-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole

Base Information

Chemical Name:2-(2,4-difluorobenzylthio)-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole
CAS No.:1444654-48-1
Molecular Formula:C₁₇H₁₄F₂N₆S₃
Molecular Weight:436.533
Hs Code.:

Synonyms:2-(2,4-difluorobenzylthio)-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole

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Chemical Property of 2-(2,4-difluorobenzylthio)-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole

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Technology Process of 2-(2,4-difluorobenzylthio)-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole

There total 5 articles about 2-(2,4-difluorobenzylthio)-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.7%

: 936099-28-4
5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole-2-thiol

: 1444654-48-1
2-(2,4-difluorobenzylthio)-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole

Guidance literature:: 5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole-2-thiol; With sodium hydroxide; In water;

2,4-difluorobenzyl halide; In water; at 20 ℃; for 18h;
DOI:10.1016/j.ejmech.2013.04.014

Reference yield:

: 51646-17-4
5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol

: 1444654-48-1
2-(2,4-difluorobenzylthio)-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water

1.2: 2 h / 20 °C

2.1: hydrazine hydrate / ethanol / 6 h / Reflux

3.1: potassium hydroxide / ethanol / 24 h / 20 °C

4.1: sulfuric acid / 24 h / 0 °C

5.1: sodium hydroxide / water

5.2: 18 h / 20 °C

With sulfuric acid; hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; water;
DOI:10.1016/j.ejmech.2013.04.014

Reference yield:

: 1171118-32-3
potassium 2-(2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)acetyl)hydrazinecarbodithioate

: 1444654-48-1
2-(2,4-difluorobenzylthio)-5-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)methyl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 24 h / 0 °C

2.1: sodium hydroxide / water

2.2: 18 h / 20 °C

With sulfuric acid; sodium hydroxide; In water;
DOI:10.1016/j.ejmech.2013.04.014