Prop-2-ene-1-sulfonic acid (2-cyclopent-2-enyl-acetyl)-phenethyl-amide

Base Information

• Chemical Name: Prop-2-ene-1-sulfonic acid (2-cyclopent-2-enyl-acetyl)-phenethyl-amide
• CAS No.: 781673-56-1
• Molecular Formula: C₁₈H₂₃NO₃S
• Molecular Weight: 333.452
• Mol file: 781673-56-1.mol

Synonyms:Prop-2-ene-1-sulfonic acid (2-cyclopent-2-enyl-acetyl)-phenethyl-amide

Chemical Property of Prop-2-ene-1-sulfonic acid (2-cyclopent-2-enyl-acetyl)-phenethyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Prop-2-ene-1-sulfonic acid (2-cyclopent-2-enyl-acetyl)-phenethyl-amide

There total 2 articles about Prop-2-ene-1-sulfonic acid (2-cyclopent-2-enyl-acetyl)-phenethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-phenethylallylsulfonamide + C12H18O4 → Prop-2-ene-1-sulfonic acid (2-cyclopent-2-enyl-acetyl)-phenethyl-amide (781673-56-1)

Guidance literature:

N-phenethylallylsulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

C₁₂H₁₈O₄; In tetrahydrofuran; hexane; at 20 ℃; for 18h;

DOI:10.1039/b405545d

Reference yield:

(cyclopent-2-eneyl)acetic acid (13668-61-6) → Prop-2-ene-1-sulfonic acid (2-cyclopent-2-enyl-acetyl)-phenethyl-amide (781673-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N / tetrahydrofuran

2.1: BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: 65 percent / hexane; tetrahydrofuran / 18 h / 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane;

DOI:10.1039/b405545d

Reference yield: 39.0%

Prop-2-ene-1-sulfonic acid (2-cyclopent-2-enyl-acetyl)-phenethyl-amide (781673-56-1) + Dithiocarbonic acid S-(1,1-dimethyl-3-oxo-butyl) ester O-ethyl ester (2048-96-6) → dithiocarbonic acid O-ethyl ester S-(1,1,3-trioxo-2-phenethyl-octahydro-1λ6-cyclopenta[e][1,2]thiazin-7-yl) ester

Guidance literature:

With dilauryl peroxide; In 1,2-dichloro-ethane; Heating;

DOI:10.1039/b405545d

upstream raw materials:

(cyclopent-2-eneyl)acetic acid