diethyl {1-[(1S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-yl}phosphonate

Base Information

• Chemical Name: diethyl {1-[(1S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-yl}phosphonate
• CAS No.: 937026-20-5
• Molecular Formula: C₁₇H₂₅FNO₄P
• Molecular Weight: 357.362

Synonyms:diethyl {1-[(1S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-yl}phosphonate

Chemical Property of diethyl {1-[(1S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-yl}phosphonate

Chemical Property:

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Technology Process of diethyl {1-[(1S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-yl}phosphonate

There total 2 articles about diethyl {1-[(1S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-yl}phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-iodopiperidin-2-one (937026-21-6) + triethyl phosphite (122-52-1) → diethyl {1-[(1S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-yl}phosphonate (937026-20-5)

Guidance literature:

at 80 ℃; for 7h; Product distribution / selectivity;

Reference yield:

1-[(1S)-1-(4-fluorophenyl)ethyl]-3-bromopiperidin-2-one (937026-31-8) + triethyl phosphite (122-52-1) → diethyl {1-[(1S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-yl}phosphonate (937026-20-5)

Guidance literature:

at 20 - 120 ℃; for 5h; Product distribution / selectivity;

Reference yield:

diethyl {1-[(1S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-yl}phosphonate (937026-20-5) + 3-methoxy-4-(5-methyltetrazol-2-yl)benzaldehyde (958228-49-4) → (E)-1-[(S)-1-(4-fluorophenyl)ethyl]-3-[1-[3-methox-4-(5-methltetrazol-2-yl)phenyl]methylidene]piperidin-2-one (958227-77-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 7.5h;

upstream raw materials:

1-[(1S)-1-(4-fluorophenyl)ethyl]-3-bromopiperidin-2-one

triethyl phosphite

1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-iodopiperidin-2-one

Downstream raw materials:

(E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one

(E)-1-[(S)-1-(4-fluorophenyl)ethyl]-3-[1-[3-methox-4-(5-methltetrazol-2-yl)phenyl]methylidene]piperidin-2-one

(E)-1-[(S)-1-(4-fluorophenyl)ethyl]-3-[1-[3-methox-4-(5-methyltetrazol-1-yl)phenyl]methylidene]piperidin-2-one

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