4-(cyclobutylidenemethyl)-3-methylene-N-(4-methylbenzenesulfonyl)-5-phenylsulfonyl-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:4-(cyclobutylidenemethyl)-3-methylene-N-(4-methylbenzenesulfonyl)-5-phenylsulfonyl-1,2,3,6-tetrahydropyridine
CAS No.:1333466-91-3
Molecular Formula:C₂₄H₂₅NO₄S₂
Molecular Weight:455.599
Hs Code.:

Synonyms:4-(cyclobutylidenemethyl)-3-methylene-N-(4-methylbenzenesulfonyl)-5-phenylsulfonyl-1,2,3,6-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(cyclobutylidenemethyl)-3-methylene-N-(4-methylbenzenesulfonyl)-5-phenylsulfonyl-1,2,3,6-tetrahydropyridine

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Technology Process of 4-(cyclobutylidenemethyl)-3-methylene-N-(4-methylbenzenesulfonyl)-5-phenylsulfonyl-1,2,3,6-tetrahydropyridine

There total 12 articles about 4-(cyclobutylidenemethyl)-3-methylene-N-(4-methylbenzenesulfonyl)-5-phenylsulfonyl-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1333466-96-8
N-(4-cyclobutyl-2-phenylsulfonyl-2,3-butadienyl)-N-(2-propynyl)-4-methylbenzenesulfonamide

: 1333466-75-3
N-(4-methylbenzenesulfonyl)-12-phenylsulfonyl-10-azabicyclo[6.4.0]dodeca-1⁽¹²⁾,2,7-triene

: 1333466-91-3
4-(cyclobutylidenemethyl)-3-methylene-N-(4-methylbenzenesulfonyl)-5-phenylsulfonyl-1,2,3,6-tetrahydropyridine

Guidance literature:: With Rh(dppp)2Cl; In 1,4-dioxane; at 80 ℃; for 0.2h; Inert atmosphere;
DOI:10.1002/chem.201101441

Reference yield: 50.0%

: 1333466-96-8
N-(4-cyclobutyl-2-phenylsulfonyl-2,3-butadienyl)-N-(2-propynyl)-4-methylbenzenesulfonamide

: 1333466-95-7
4-cyclobutyl-2-phenylsulfonylbut-1-en-3-yne

: 1333466-91-3
4-(cyclobutylidenemethyl)-3-methylene-N-(4-methylbenzenesulfonyl)-5-phenylsulfonyl-1,2,3,6-tetrahydropyridine

Guidance literature:: With [Rh(1,2-bis(diphenylphosphino)ethane)2Cl]; In toluene; at 80 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/chem.201101441

Reference yield:

: 18773-54-1
4-methyl-N,N-diprop-2-ynylbenzenesulfonamide

: 1333466-91-3
4-(cyclobutylidenemethyl)-3-methylene-N-(4-methylbenzenesulfonyl)-5-phenylsulfonyl-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.08 h / -78 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / -78 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: [Rh(1,2-bis(diphenylphosphino)ethane)2Cl] / toluene / 0.5 h / 80 °C / Inert atmosphere

With [Rh(1,2-bis(diphenylphosphino)ethane)2Cl]; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.201101441