(S)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester

Base Information

• Chemical Name: (S)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester
• CAS No.: 177904-35-7
• Molecular Formula: C₁₆H₂₆O₃SSi
• Molecular Weight: 326.532
• Mol file: 177904-35-7.mol

Synonyms:(S)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester

Chemical Property of (S)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester

There total 2 articles about (S)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethylthio-1-(trimethylsiloxy)ethene (63584-41-8) + benzyloxyacetoaldehyde (60656-87-3) → (S)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester (177904-35-7)

Guidance literature:

With bis(oxazolinyl)pyridine (pybox) Cu(II)SbF₆-; In dichloromethane; at -78 ℃;

DOI:10.1021/ja960712i

Reference yield:

1-ethylthio-1-(trimethylsiloxy)ethene (63584-41-8) + benzyloxyacetoaldehyde (60656-87-3) → (S)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester (177904-35-7) + (R)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester

Guidance literature:

With (R)-binaphthol-titanium dichloride ((R)-BINOL-TiCl₂); In toluene; at 0 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00088a053

Reference yield:

(S)-4-Benzyloxy-3-trimethylsilanyloxy-thiobutyric acid S-ethyl ester (177904-35-7) → (S)-ethyl 4-benzyloxy-3-hydroxybutanethioate

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; Yield given;

DOI:10.1021/ja960712i

upstream raw materials:

1-ethylthio-1-(trimethylsiloxy)ethene

benzyloxyacetoaldehyde