4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carbaldehyde

Base Information

Chemical Name:4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carbaldehyde
CAS No.:1218994-94-5
Molecular Formula:C₁₈H₁₉FN₆O
Molecular Weight:354.387
Hs Code.:

Synonyms:4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carbaldehyde

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Chemical Property of 4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carbaldehyde

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Technology Process of 4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carbaldehyde

There total 4 articles about 4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

: 1218994-93-4
(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-yl)methanol

: 1218994-94-5
4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carbaldehyde

Guidance literature:: With sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-ol; potassium bromide; In water; ethyl acetate; at -5 - 5 ℃; Inert atmosphere; Large scale reaction;
DOI:10.1021/op100010n

Reference yield:

: 1218994-92-3
methyl (4-(4-fluorophenyl)-6-isopropyl-2-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carboxylate

: 1218994-94-5
4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / 88 - 90 °C / Inert atmosphere; Large scale reaction

2: diisobutylaluminium hydride / toluene / -15 - -5 °C / Large scale reaction

3: sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-ol; potassium bromide / water; ethyl acetate / -5 - 5 °C / Inert atmosphere; Large scale reaction

With 1,4-diaza-bicyclo[2.2.2]octane; sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-ol; diisobutylaluminium hydride; potassium bromide; In water; ethyl acetate; toluene;
DOI:10.1021/op100010n

Reference yield:

: 488798-38-5
2-chloro-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid methyl ester

: 1218994-94-5
4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 - 25 °C / Inert atmosphere; Large scale reaction

2: 1,4-diaza-bicyclo[2.2.2]octane / 88 - 90 °C / Inert atmosphere; Large scale reaction

3: diisobutylaluminium hydride / toluene / -15 - -5 °C / Large scale reaction

4: sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-ol; potassium bromide / water; ethyl acetate / -5 - 5 °C / Inert atmosphere; Large scale reaction

With 1,4-diaza-bicyclo[2.2.2]octane; sodium hypochlorite; 2,2,6,6-tetramethylpiperidin-1-ol; potassium tert-butylate; diisobutylaluminium hydride; potassium bromide; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op100010n