1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylthio)phenyl)urea

Base Information

Chemical Name:1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylthio)phenyl)urea
CAS No.:1349828-23-4
Molecular Formula:C₃₀H₃₆N₆O₅S
Molecular Weight:592.719
Hs Code.:

Synonyms:1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylthio)phenyl)urea

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Chemical Property of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylthio)phenyl)urea

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Technology Process of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylthio)phenyl)urea

There total 7 articles about 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylthio)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 110-91-8,99108-56-2
morpholine

: 1188907-71-2
1-(5-tert-butylisoxazol-3-yl)-3-(3-(7-(3-chloropropoxy)-6-methoxyquinazolin-4-ylthio)phenyl)urea

: 1349828-23-4
1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylthio)phenyl)urea

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃; for 15h;

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 1349828-23-4
1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylthio)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

2: nitric acid; acetic anhydride / water; acetic acid / 0 - 50 °C

3: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 12 h

4: ethanol / 12 h / 140 °C

5: trichlorophosphate / toluene / 5 h / 125 °C

6: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C

7: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 60 °C

With hydrogen; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 111627-40-8
methyl 4-(3-chloropropoxy)-3-methoxybenzoate

: 1349828-23-4
1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylthio)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid; acetic anhydride / water; acetic acid / 0 - 50 °C

2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 12 h

3: ethanol / 12 h / 140 °C

4: trichlorophosphate / toluene / 5 h / 125 °C

5: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C

6: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 60 °C

With hydrogen; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene;