naphtho[2,1-b]furan-2-yl-[1-phenyl-3-(thiophene-2-carbonyl)-1H-pyrazol-4-yl]-methanone

Base Information

• Chemical Name: naphtho[2,1-b]furan-2-yl-[1-phenyl-3-(thiophene-2-carbonyl)-1H-pyrazol-4-yl]-methanone
• CAS No.: 860269-18-7
• Molecular Formula: C₂₇H₁₆N₂O₃S
• Molecular Weight: 448.502

Synonyms:naphtho[2,1-b]furan-2-yl-[1-phenyl-3-(thiophene-2-carbonyl)-1H-pyrazol-4-yl]-methanone

Chemical Property of naphtho[2,1-b]furan-2-yl-[1-phenyl-3-(thiophene-2-carbonyl)-1H-pyrazol-4-yl]-methanone

Chemical Property:

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Technology Process of naphtho[2,1-b]furan-2-yl-[1-phenyl-3-(thiophene-2-carbonyl)-1H-pyrazol-4-yl]-methanone

There total 2 articles about naphtho[2,1-b]furan-2-yl-[1-phenyl-3-(thiophene-2-carbonyl)-1H-pyrazol-4-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

3-(dimethylamino)-1-naphtho[2,1-b]furan-2-ylprop-2-en-1-one → naphtho[2,1-b]furan-2-yl-[1-phenyl-3-(thiophene-2-carbonyl)-1H-pyrazol-4-yl]-methanone (860269-18-7)

Guidance literature:

With triethylamine; In toluene; for 3h; Heating;

DOI:10.1002/jhet.5570420409

Reference yield:

1-(naphtho[2,1-b]furan-2-yl)ethan-1-one (49841-22-7) → naphtho[2,1-b]furan-2-yl-[1-phenyl-3-(thiophene-2-carbonyl)-1H-pyrazol-4-yl]-methanone (860269-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / xylene / 4 h / Heating

2: 59 percent / Et₃N / toluene / 3 h / Heating

With triethylamine; In toluene; xylene;

DOI:10.1002/jhet.5570420409

Reference yield: 70.0%

naphtho[2,1-b]furan-2-yl-[1-phenyl-3-(thiophene-2-carbonyl)-1H-pyrazol-4-yl]-methanone (860269-18-7) → 4-naphtho[2,1-b]furan-2-yl-2-phenyl-7-thiophen-2-yl-2H-pyrazolo[3,4-d]pyridazine

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1002/jhet.5570420409

upstream raw materials:

1-(naphtho[2,1-b]furan-2-yl)ethan-1-one

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