N-acetyl-1-benzyl-L-histidine benzyl ester

Base Information

• Chemical Name: N-acetyl-1-benzyl-L-histidine benzyl ester
• CAS No.: 119998-67-3
• Molecular Formula: C₂₂H₂₃N₃O₃
• Molecular Weight: 377.443
• Mol file: 119998-67-3.mol

Synonyms:N-acetyl-1-benzyl-L-histidine benzyl ester

Chemical Property of N-acetyl-1-benzyl-L-histidine benzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-acetyl-1-benzyl-L-histidine benzyl ester

There total 1 articles about N-acetyl-1-benzyl-L-histidine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

acetic anhydride (108-24-7) + 1-benzyl-L-histidine benzyl ester (42569-10-8) → N-acetyl-1-benzyl-L-histidine benzyl ester (119998-67-3)

Guidance literature:

With acetic acid; for 0.75h; Heating;

DOI:10.1021/jm00126a030

Reference yield: 43.0%

N-acetyl-1-benzyl-L-histidine benzyl ester (119998-67-3) → 1-benzyl-4-<2'-(ethylamino)-3'-hydroxypropyl>imidazole (119998-68-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 16h; Heating;

DOI:10.1021/jm00126a030

Reference yield:

N-acetyl-1-benzyl-L-histidine benzyl ester (119998-67-3) → 1-benzyl-4-<2'--3'-hydroxypropyl>imidazole (119998-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

2: 32 percent / aq. LiOH / dioxane / 0.75 h / Ambient temperature

With lithium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm00126a030

upstream raw materials:

acetic anhydride

1-benzyl-L-histidine benzyl ester

Downstream raw materials:

1-benzyl-4-<2'-(ethylamino)-3'-hydroxypropyl>imidazole

1-benzyl-4-<2'--3'-hydroxypropyl>imidazole