dimethyl 2-{[methoxy(2-methyl-1-{[(4-nitrobenzyl)sulfonyl]amino}butyl)phosphoryl]methyl}pentanedioate

Base Information

Chemical Name:dimethyl 2-{[methoxy(2-methyl-1-{[(4-nitrobenzyl)sulfonyl]amino}butyl)phosphoryl]methyl}pentanedioate
CAS No.:939403-26-6
Molecular Formula:C₂₁H₃₃N₂O₁₀PS
Molecular Weight:536.54
Hs Code.:

Synonyms:dimethyl 2-{[methoxy(2-methyl-1-{[(4-nitrobenzyl)sulfonyl]amino}butyl)phosphoryl]methyl}pentanedioate

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Chemical Property of dimethyl 2-{[methoxy(2-methyl-1-{[(4-nitrobenzyl)sulfonyl]amino}butyl)phosphoryl]methyl}pentanedioate

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Technology Process of dimethyl 2-{[methoxy(2-methyl-1-{[(4-nitrobenzyl)sulfonyl]amino}butyl)phosphoryl]methyl}pentanedioate

There total 7 articles about dimethyl 2-{[methoxy(2-methyl-1-{[(4-nitrobenzyl)sulfonyl]amino}butyl)phosphoryl]methyl}pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939403-20-0
methyl 1-{[(benzyloxy)carbonyl]amino}-2-methylbutylphosphinate

: 939403-26-6
dimethyl 2-{[methoxy(2-methyl-1-{[(4-nitrobenzyl)sulfonyl]amino}butyl)phosphoryl]methyl}pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: 34.2 percent / NaOMe / methanol / 20 °C

2: H₂ / Pd/C / methanol / 1292.9 Torr

3: Et₃N / CH₂Cl₂ / 0 - 20 °C

With hydrogen; sodium methylate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/ardp.200600191

Reference yield:

: 939403-22-2
dimethyl 2-{[(1-{[(benzyloxy)carbonyl]amino}-2-methylbutyl)(methoxy)phosphoryl]methyl}pentanedioate

: 939403-26-6
dimethyl 2-{[methoxy(2-methyl-1-{[(4-nitrobenzyl)sulfonyl]amino}butyl)phosphoryl]methyl}pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 1292.9 Torr

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/ardp.200600191

Reference yield:

: 96-17-3,57456-98-1
2-Methylbutyraldehyde

: 939403-26-6
dimethyl 2-{[methoxy(2-methyl-1-{[(4-nitrobenzyl)sulfonyl]amino}butyl)phosphoryl]methyl}pentanedioate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 28.3 percent / aq. phosphinic acid / 2 h / Heating

2.1: conc. HCl / 12 h / Heating

2.2: 28.3 percent / propylene oxide / ethanol

3.1: 72.2 percent / aq. NaOH / dioxane / 0 - 20 °C / pH 9 - 10

4.1: EDC / 12 h

5.1: 34.2 percent / NaOMe / methanol / 20 °C

6.1: H₂ / Pd/C / methanol / 1292.9 Torr

7.1: Et₃N / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; sodium methylate; hypophosphorous acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1002/ardp.200600191