(R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-(p-tolyl)acetate

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Chemical Name:(R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-(p-tolyl)acetate
CAS No.:1312945-60-0
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:(R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-(p-tolyl)acetate

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Chemical Property of (R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-(p-tolyl)acetate

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Technology Process of (R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-(p-tolyl)acetate

There total 2 articles about (R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-(p-tolyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 941-69-5
N-phenyl-maleimide

: 147795-55-9,39266-20-1
ethyl 2-cyano-2-(p-tolyl)acetate

: 1312945-60-0
(R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-(p-tolyl)acetate

: C₂₂H₂₀N₂O₄

Guidance literature:: With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; In 5,5-dimethyl-1,3-cyclohexadiene; at 20 ℃; for 7h; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tetasy.2011.04.009

Reference yield:

: 941-69-5
N-phenyl-maleimide

: 147795-55-9,39266-20-1
ethyl 2-cyano-2-(p-tolyl)acetate

: 1312945-60-0
(R)-ethyl 2-cyano-2-((S)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-(p-tolyl)acetate

: (S)-ethyl 2-cyano-2-((R)-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-(p-tolyl)acetate

Guidance literature:: With C₃₁H₅₃N₃O₂S; In toluene; at -30 ℃; for 2h; Overall yield = 96 %; enantioselective reaction;
DOI:10.1016/j.tetasy.2012.11.009