(+/-)-1-(3-((4'-cyano-(1,1'-biphenyl)-4-yl)oxy)-propan-2-on-1-yl)-3,4,4-trimethyl-2,5-dioxoimidazolidine

Base Information

• Chemical Name: (+/-)-1-(3-((4'-cyano-(1,1'-biphenyl)-4-yl)oxy)-propan-2-on-1-yl)-3,4,4-trimethyl-2,5-dioxoimidazolidine
• CAS No.: 220615-33-8
• Molecular Formula: C₂₂H₂₁N₃O₄
• Molecular Weight: 391.426
• Mol file: 220615-33-8.mol

Synonyms:(+/-)-1-(3-((4'-cyano-(1,1'-biphenyl)-4-yl)oxy)-propan-2-on-1-yl)-3,4,4-trimethyl-2,5-dioxoimidazolidine

Chemical Property of (+/-)-1-(3-((4'-cyano-(1,1'-biphenyl)-4-yl)oxy)-propan-2-on-1-yl)-3,4,4-trimethyl-2,5-dioxoimidazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-1-(3-((4'-cyano-(1,1'-biphenyl)-4-yl)oxy)-propan-2-on-1-yl)-3,4,4-trimethyl-2,5-dioxoimidazolidine

There total 7 articles about (+/-)-1-(3-((4'-cyano-(1,1'-biphenyl)-4-yl)oxy)-propan-2-on-1-yl)-3,4,4-trimethyl-2,5-dioxoimidazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-Cyano-4'-hydroxybiphenyl (19812-93-2) + 3-(3-bromo-2-oxopropyl)-1,5,5-trimethylimidazolidine-2,4-dione (220615-58-7) → (+/-)-1-(3-((4'-cyano-(1,1'-biphenyl)-4-yl)oxy)-propan-2-on-1-yl)-3,4,4-trimethyl-2,5-dioxoimidazolidine (220615-33-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00032-4

Reference yield:

4-Cyano-4'-hydroxybiphenyl (19812-93-2) → (+/-)-1-(3-((4'-cyano-(1,1'-biphenyl)-4-yl)oxy)-propan-2-on-1-yl)-3,4,4-trimethyl-2,5-dioxoimidazolidine (220615-33-8)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / tetrahydrofuran

2: 91 percent / I₂; Ph₃P / CH₂Cl₂

3: 75 percent / Dess-Martin reagent / CH₂Cl₂

4: K₂CO₃ / dimethylformamide

With iodine; potassium carbonate; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Dess-Martin oxidation;

DOI:10.1016/S0960-894X(01)00031-2

Reference yield:

1,5,5-trimethylhydantoin (6851-81-6) → (+/-)-1-(3-((4'-cyano-(1,1'-biphenyl)-4-yl)oxy)-propan-2-on-1-yl)-3,4,4-trimethyl-2,5-dioxoimidazolidine (220615-33-8)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide

2: NBS; K₂CO₃ / acetone

3: 75 percent / Cs₂CO₃ / dimethylformamide

With N-Bromosuccinimide; potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0960-894X(01)00032-4

upstream raw materials:

1,5,5-trimethylhydantoin

4'-(3-iodo-2-oxo-propoxy)-biphenyl-4-carbonitrile

4-Cyano-4'-hydroxybiphenyl

3-(3-bromo-2-oxopropyl)-1,5,5-trimethylimidazolidine-2,4-dione

Downstream raw materials:

4'-[2-hydroxyamino-3-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-propoxy]-biphenyl-4-carbonitrile