3-{2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-pyridin-2-ol

Base Information

Chemical Name:3-{2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-pyridin-2-ol
CAS No.:1355999-65-3
Molecular Formula:C₂₈H₂₄N₄O
Molecular Weight:432.525
Hs Code.:

Synonyms:3-{2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-pyridin-2-ol

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Chemical Property of 3-{2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-pyridin-2-ol

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Technology Process of 3-{2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-pyridin-2-ol

There total 4 articles about 3-{2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-pyridin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356001-97-2
1-{4-[6-(2-benzyloxy-pyridin-3-yl)-3-phenyl-imidazo[1,2-a]pyridin-2-yl]-phenyl}-cyclobutylamine

: 1355999-65-3
3-{2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-pyridin-2-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃;

Reference yield:

: 1356000-09-3
{1-[4-(6-bromo-3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

: 1355999-65-3
3-{2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-pyridin-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 3.5 h / 100 °C / Inert atmosphere; microwave irradiation

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; 1,4-dioxane; water / 0.5 h / 110 °C / microwave irradiation

3: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 2 h / 0 - 20 °C

4: hydrogen / palladium on activated charcoal / ethanol / 50 °C

With hydrogenchloride; hydrogen; potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1356001-95-0
(1-{4-[3-phenyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-imidazo[1,2-a]pyridin-2-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester

: 1355999-65-3
3-{2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-pyridin-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; 1,4-dioxane; water / 0.5 h / 110 °C / microwave irradiation

2: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 2 h / 0 - 20 °C

3: hydrogen / palladium on activated charcoal / ethanol / 50 °C

With hydrogenchloride; hydrogen; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;