(3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

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Chemical Name:(3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one
CAS No.:1613395-34-8
Molecular Formula:C₂₂H₂₃ClF₃N₅O₂
Molecular Weight:481.905
Hs Code.:

Synonyms:(3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

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Chemical Property of (3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

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Technology Process of (3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

There total 13 articles about (3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1613396-79-4
C₂₃H₂₇ClF₃N₅O₅S

: 1613395-34-8
(3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at 60 ℃; for 2h;

Reference yield:

: C₁₈H₂₁F₃N₂O₃

: 1613395-34-8
(3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 1,4-dioxane / 1 h / 80 °C

2: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0.5 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.25 h / 20 °C

4: triethylamine / 1,2-dichloro-ethane / 2 h / 60 °C

With sulfuric acid; trimethylaluminum; triethylamine; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1613396-98-7
(3R)-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]tetrahydrofuran-2-one

: 1613395-34-8
(3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0.5 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.25 h / 20 °C

3: triethylamine / 1,2-dichloro-ethane / 2 h / 60 °C

With trimethylaluminum; triethylamine; In dichloromethane; 1,2-dichloro-ethane; toluene;