3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

Base Information

• Chemical Name: 3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
• CAS No.: 1394896-93-5
• Molecular Formula: C₂₅H₁₉F₂N₅S
• Molecular Weight: 459.522
• Mol file: 1394896-93-5.mol

Synonyms:3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

Chemical Property of 3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide

There total 4 articles about 3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-(2-fluorophenyl)-3-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-one (1394896-81-1) + thiosemicarbazide (79-19-6) → 3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide (1394896-93-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 8h; Reflux;

DOI:10.1016/j.jfluchem.2012.06.021

Reference yield:

1-(1-(4-fluorophenyl)ethylidene)-2-phenylhydrazine (1994-40-7) → 3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide (1394896-93-5)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 5 h / 70 - 80 °C

2: sodium hydroxide / methanol / 24 h / 20 °C

3: sodium hydroxide / ethanol / 8 h / Reflux

With sodium hydroxide; trichlorophosphate; In methanol; ethanol;

DOI:10.1016/j.jfluchem.2012.06.021

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide (1394896-93-5)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 1 h / Reflux

2: trichlorophosphate / 5 h / 70 - 80 °C

3: sodium hydroxide / methanol / 24 h / 20 °C

4: sodium hydroxide / ethanol / 8 h / Reflux

With acetic acid; sodium hydroxide; trichlorophosphate; In methanol; ethanol;

DOI:10.1016/j.jfluchem.2012.06.021

upstream raw materials:

1-(1-(4-fluorophenyl)ethylidene)-2-phenylhydrazine

1-(2-fluorophenyl)-3-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-one

thiosemicarbazide

1-(4-fluorophenyl)ethanone

Downstream raw materials:

2-(3-(2-fluorophenyl)-5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one